Uncovering Brain Anatomy/Function/Relationships using Biologic Parametric Mapping

描述(由候选人提供)： 本附录的目的是在NIBIB资助的研究人员的指导下，为临床住院医师提供有组织的一年的研究培训。这项补充的家长拨款由两部分组成：神经信息学部分和生物部分。家长赠款的神经信息学部分将开发多个工具箱，包括生物参数映射工具箱(BPM)，用于对将在当前补编中使用的多模式图像数据进行统计分析。在本补充资料中，将使用BPM工具箱进行多变量回归分析，以评估功能性MRI激活和结构解剖之间的年龄相关关系。Deibler博士的研究项目的主要假设是，灰质体积与年龄相关的变化以一种区域特有的方式预测大脑的功能活动。这项分析将控制灰质浓度的差异。Deibler博士将接受使用BPM工具箱的培训，他将实施 使用母项目中的神经信息学工具对数据进行分析。Deibler博士的教育培训计划包括四个要素：1)通过统计学、神经科学的教学课程工作以及参加期刊俱乐部会议和机构研讨会来发展知识；2)通过在导师的指导下进行研究设计、数据收集和数据分析来掌握脑成像研究技能；3)在维克森林大学神经生物学和解剖学系引入基础神经生理学研究；以及4)研究伦理和医疗行为方面的培训。

DESCRIPTION (provided by candidate): The objective of this supplement is to provide a structured year of research training to a clinical resident under the mentorship of a NIBIB funded investigator. The parent grant for this supplement is composed of two components: a neuroinformatics component and a biologic component. The neuroinformatics component of the parent grant will develop multiple toolboxes including a biologic parametric mapping toolbox (BPM) for the statistical analysis of multimodal image data to be used in the current supplement. In this supplement, the BPM toolbox will be used to perform a multiple variable regression analysis to evaluate age-related relationships between functional MRI activation and structural anatomy. The overarching hypothesis for Dr. Deibler's research project is that age-related changes in grey matter volume are predictive of functional brain activity in a regionally specific manner. This analysis will control for differences in grey matter concentration. Dr. Deibler will be trained in the use of the BPM toolbox and he will implement the analyses of the data using the neuroinformatics tools from the parent project. The educational training plan proposed for Dr. Deibler has four elements: 1) development of knowledge through didactic course work in statistics, neuroscience, as well as attending journal club meetings and institutional seminars; 2) mastery of brain imaging research skills through study design, data collection, and data analyses under mentor guidance; 3) introduction to basic neurophysiologic research in the Department of Neurobiology and Anatomy at Wake Forest University; and 4) training in research ethics and medical conduct.