CORE--TUMOR BANK

肿瘤库设施(TBF)是福克斯大通癌症中心(Fccc)的集中资源。 被指定为正常组织和肿瘤组织的来源，用于癌症研究。TBF负责收集、储存和分发正常和肿瘤标本(新鲜的、冷冻的或石蜡包埋的)，这些标本来自于在fccc接受手术治疗的同意患者。自我们上次审查的那一年以来，应计利润增加了50%(1999年为500份，2003年为751份)。冷冻样品的使用稳定在每年600个样品左右，2002年达到848个样品的峰值(过去四年的范围：每年569-848个样品)。人体组织石蜡切片的年使用量稳定在2,000-4,000份之间，而切片石蜡组织微阵列(TMA)切片在2003年稳步增长至150份，2004年继续增长。此外，TBF继续为fccc调查人员提供全面的病理学支持，包括技术和解释方面的支持。自上次审查以来，我们实施了以下新的政策和服务：1)成立了一个新的优先处理小组委员会；2)我们增加了累积组织的数量及其相应的等量；3)我们引入了TMA，并从正常组织和肿瘤组织中提取核酸，以最大限度地减少对银行标本的消耗。TMA的引入非常成功，有助于减少宝贵组织的消耗。目前共有35个TMA可用(总计1891个组织核心)。我们在2002年分发了40个TMA部分，在2003年分发了149个部分。同样，我们已经开始提取核酸并将其分发给三名调查人员(2003年总共采集了73份样本)。4)建立了一个新的网上数据录入系统和数据库。TBF与人口研究机构密切合作，确保关键的临床信息与我们每一个未确认的组织样本相联系。我们所有的捐赠者都是按照NIH的指导方针同意的。该机构遵循既定的质量控制(QC)指南，组织只分发给IRB批准的项目。此外，所有业务、优先次序和分配活动都由肿瘤库和生物样本库咨询委员会监督。这一设施由24名同行评审者使用 来自所有三个部门的七个不同项目的调查人员。77% (77%)是由拥有同行审查资金的调查人员使用的。

The Tumor Bank Facility (TBF) is a centralized resource for Fox Chase Cancer Center (FCCC) designated as the source of normal and tumor tissues for cancer research. The TBF is responsible for collecting, banking, and distributing normal and tumor specimens (fresh, frozen, or paraffin-embedded) accrued from consented patients treated surgically at FCCC. Accrual has increased 50% since the year of our last review (500 in 1999 versus 751 specimens in 2003). Usage of frozen samples has stabilized around 600 samples a year, peaking at 848 in 2002 (range during the last four years: 569-848 samples per year). The annual usage of paraffin sections of human tissues has stabilized between 2,000-4,000, whereas cut paraffin tissue microarray (TMA) sections grew steadily to 150 in 2003 and 2004 shows continued growth. In addition, the TBF continues to provide comprehensive pathology support, both at the technical and interpretative levels for FCCC investigators. Since our last review, the following new policies and services have been implemented: 1) a new Prioritization Subcommittee has been established, 2) we have increased the number of accrued tissues and their respective aliquots, 3) we introduced TMAs and extraction of nucleic acids from normal and neoplastic tissues to minimize depletion of our banked specimens. The introduction of TMAs has been very successful and has helped to reduce depletion of valuable tissues. A total of 35 TMAs are now available (total 1,891 tissue cores). We have distributed 40 TMA sections in 2002 and 149 sections in 2003. Similarly, we have started extracting and distributing nucleic acids to three investigators (total 73 samples in 2003. 4) A new Web-based data entry-system and database has been created. The TBF works closely with the Population Studies Facility to ensure that critical clinical information is linked to each of our de-identified tissue specimens. All our donors have been consented following NIH guidelines. The Facility follows the established guidelines of quality control (QC) and tissues are distributed only to IRB-approved projects. Furthermore, all operations, prioritization and distribution activities are overseen by the Tumor Bank and Biosample Repository Advisory Committee. This Facility is utilized by 24 peer-reviewed investigators from seven different Programs in all three Divisions. Seventy-seven percent (77%) of its use is by investigators with peer-reviewed funding.