CORE--POPULATION STUDIES

福克斯·蔡斯癌症中心的大型和后勤复杂研究的数量 (Fcc)一直在稳步增长。Fccc的许多研究，包括流行病学、癌症控制和预防、转化研究、人类遗传学、行为医学和一些动物试验，采用了各种设计，这些设计比fccc的典型癌症临床试验要复杂得多。这些研究的设计通常包括：来自大量个人(从数百到数万人不等)的独特问卷、临床和标本数据；纵向数据的收集；系谱数据的收集、存储和图形显示；多个地理位置遥远的中心的在线数据输入和检索；使用计算机辅助电话访谈系统收集数据；开发标本库存系统；病例对照和嵌套病例对照研究设计；分发预定的个性化邮件，以及收集、整合、协调和检索来自不同来源并可能存储在多个系统中的信息。这些项目研究的人群多种多样，设计的多样性和复杂性要求开发专门针对研究的计算机工具，以提供项目管理和协调，以及数据的收集、验证、存储和检索。人口研究基金(人口研究基金)利用同行审查的资金促进了《气候变化框架公约》调查员开展的研究，使他们能够接触到一支由熟练的信息系统专业人员组成的富有成效的团队。PSF人员在最先进的软件方面拥有丰富的专业知识 应用于癌症研究的工程和设计。PSF的职能包括制定： (A)用于存储和处理大量问卷、临床和 标本数据；(B)电子数据输入和检索系统；(C)报告生成软件； (D)一致性和质量控制系统；和(E)提供综合和受控交换来自不同来源的数据的系统。PSF开发了信息系统，维护着超过14.8万个研究对象的数据。在过去五年中，该机制向40名调查员提供了来自所有三个司的10个方案的同行审查资金，比上一个供资周期增加了38%。99%的设施使用是由拥有同行审查资金的调查人员使用的。

The number of large and logistically intricate research studies at Fox Chase Cancer Center (FCCC) has been steadily increasing. Many FCCC studies, including those in epidemiology, cancer control and prevention, translational research, human genetics, behavioral medicine and some animal trials employ a variety of designs that are substantially more complex than typical cancer clinical trials at FCCC. The designs of these studies often include: unique questionnaires, clinical and specimen data from large numbers of individuals (ranging from hundreds to tens of thousands); collection of longitudinal data; collection, storage and graphical display of pedigree data; online data entry and retrieval at multiple geographically distant centers; data collection using computer-aided telephone interview systems; development of specimen inventory systems; case-control and nested case-control study designs; distribution of scheduled, personalized mailings, and the collection, integration, coordination and retrieval of information generated from diverse sources and potentially stored in multiple systems. The varied populations studied in these projects and the diversity and complexity of the designs require development of study-specific computer-based tools to provide project management and coordination, and for the collection, validation, storage, and retrieval of data. The Population Studies Facility (PSF) facilitates research conducted by FCCC investigators with peer-reviewed funding by providing them access to a productive team of skilled information systems professionals. PSF personnel have substantial expertise with states-of-the-art software engineering and design as applied to cancer research. The PSF functions include development of: (a) databases for the storage and manipulation of large quantities of questionnaire, clinical, and specimen data; (b) electronic data entry and retrieval systems; (c) report generation software; (d) consistency and quality control systems; and (e) systems that provide integration and controlled exchange of data from diverse sources. The PSF developed information systems that maintain data on over 148,000 study subjects. Over the last five years, the Facility provided services to 40 investigators with peer-reviewed funding in 10 Programs from all three Divisions, representing a 38% increase over the previous funding cycle. 99% of Facility use is by investigators with peer-reviewed funding.