Correlating Human Electrophysiology and BOLD Activity

描述（由申请人提供）：本提案的目标是将血液动力学BOLD信号与人类内侧颞叶的细胞电生理活动联系起来。本项目拟对执行导航任务时的海马区进行高分辨率结构成像研究。使用计算方法，允许在大脑的亚区展开活动，我将检查fMRI BOLD活动在海马体的亚核和海马体旁区特定层。这些患者随后将在这些脑区植入深度电极，作为治疗药理学上难治性癫痫的切除计划的一部分。使用128通道记录系统，允许宽带电生理数据的连续采样，脑电图和海马区的单个神经元反应将被检查。通过检查脑电图和单个神经元对行为相关事件的反应，这些信号将与BOLD信号相关联。对照受试者的测试将提供洞察患者的哪些激活可能代表癫痫引起的损伤，并可以证明将我们的发现与BOLD和电生理与正常大脑活动之间的相关性进行比较。

DESCRIPTION (provided by applicant): The goal of this proposal is to correlate the hemodynamic BOLD signal with cellular electrophysiological activity in the human medial temporal lobes. This project proposes to perform high-resolution structural imaging studies of the hippocampal area during performance of navigation tasks. Using computational methods that allow unfolding of activity in subregions of the brain, I will examine fMRI BOLD activity in the subnuclei of the hippocampus and specific layers of the parahippoccampal region. These same patients will subsequently be implanted with depth electrodes in these brain regions as part of resection planning for treatment of pharmacologically intractable epilepsy. Using an 128 channel recording system that allows continuous sampling of wide band electrophysiological data, both EEG and single neuron responses in the hippocampal area will be examined. By examining EEG and single neuron responses to behaviorally relevant events, these signals will then be correlated with the BOLD signal. Testing with control subjects will provide insight into which activations in patients may represent impairments due to seizures and can justify comparing our findings on correlations between BOLD and electrophysiology to normal brain activity.