Fifth Conference on Ultrasonic Biomicroscopy 2006

描述(由申请人提供)：本提案申请资金，以允许5名美国博士/博士后学生和3名初级教职研究员出席第五届国际超声生物显微镜会议(UBM)并在会上展示他们的研究成果，该会议致力于快速发展的高分辨率医学成像领域，该学科在其他会议上只有部分讨论。UBM会议由特设委员会每两年举行一次，以促进UBM的进一步发展。UBM使用高频(近50 MHz)宽带换能器提供接近30微米的体内分辨率。正在探索的临床应用实例包括：前眼(诊断眼肿瘤和青光眼病因)；皮肤(黑色素瘤、牛皮癣等)；血流灌注测量；血管斑块脆弱性(通过血管内探头)；以及手术内组织。在体内对转基因小鼠进行UBM检查，可以在不牺牲动物的情况下，对一段时间内的发育异常进行一系列研究。甚高频声学显微镜可以检查活的未染色细胞，分辨率至少可以与光学显微镜相媲美。UBM会议将于2006年9月12-15日在法国卡尔吉斯(科西嘉岛)的科学研究所举行。其目标是：评估当前UBM的最新水平；促进不同多学科UBM领域的交流；确定关键问题和解决方案；与其他高分辨率成像模式的专家分享见解；以及促进青年科学家和学生与更多资深科学家互动的环境。参与者包括具有多学科专业知识的研究人员，包括：生物医学工程、医学成像、换能器制造、声学以及高分辨率动物和临床应用。其他高分辨率技术方面的专家将对UBM的最终作用提出看法。主题将包括多学科UBM领域，包括：高频换能器制造；新系统概念；UBM频率下的散射模型和声学现象；3-D UBM成像；小鼠成像；血流和斑块分析；临床检查(眼睛、皮肤等)；声细胞显微镜；补充高分辨率模式(例如OCT、特殊MRI设备)。因此，这次会议应该直接关系到NIH的各个分支机构，包括NIBIB、NCI、NHLBI和NEI。

DESCRIPTION (provided by applicant): This proposal requests funds to permit 5 U.S.-based doctoral/post-doctoral students and 3 junior faculty researchers to attend and present their research at the Fifth International Conference on Ultrasonic Biomicroscopy (UBM), a conference dedicated to the rapidly developing field of high-resolution medical imaging, a discipline only partially addressed at other conferences. The UBM conference is held every 2 years by ad-hoc committees to stimulate further developments in UBM. UBM employs high-frequency (near 50 MHz) broadband transducers to provide in vivo resolution near 30 mu m. Examples of clinical applications being explored include: the anterior eye (to diagnose ocular tumors and glaucoma etiology); skin (melanomas, psoriasis, etc.); perfusion measurements; vascular-plaque vulnerability (via intravascular probes); and intrasurgical tissues. In vivo UBM examinations of genetically altered mice are permitting serial studies of developmental anomalies over time, without sacrificing animals. Very-high-frequency acoustic microscopy can examine living unstained cells with resolution at least comparable to optical microscopy. The UBM conference will convene on September 12-15, 2006 at the Institut d'Etudes Scientifiques in Cargese (on Corsica), France. Its goals are: assess the current state-of-the-art in UBM; foster communication among diverse multi-disciplinary UBM fields; identify key problems and solutions; share insights with experts in other high-resolution imaging modalities; and, foster an environment where young scientists and students can interact with more senior scientists. Participants include investigators with multidisciplinary expertise including: biomedical engineering, medical imaging, transducer fabrication, acoustics, and high-resolution animal and clinical applications. Experts in other high-resolution techniques will lend perspective regarding the ultimate role of UBM. Topics will include multidisciplinary UBM areas including: high-frequency transducer fabrication; new system concepts; scattering models and acoustic phenomena at UBM frequencies; 3-D UBM imaging; mice imaging; blood flow and plaque assays; clinical examinations (eye, skin, etc.); acoustic cell microscopy; complementary high-resolution modalities (e.g., OCT, special MRI units). Thus, the meeting should be of direct interest to various branches of NIH including NIBIB, NCI, NHLBI, and NEI.