Functional Organization of Audition in Schizophrenia

描述(申请人提供)：精神分裂症患者的基本听觉变化已经被注意到一段时间了，但关于听觉行为功能的变化如何与解剖学和生理学的潜在变化相关的了解很少。听觉表现差与疾病的显著临床症状之间的关系，如幻听，也是知之甚少。我们提议再资助5年，以继续努力描述精神分裂症患者听觉皮质基本组织原则的变化，以及它们与听觉心理物理学、临床症状学和工作记忆的关系。脑磁图(MEG)、磁共振成像(MRI)和心理声学方法将被用来研究80名精神分裂症患者和匹配的对照组的这些关系。我们假设，精神分裂症患者听觉知觉过程的根本变化是听觉生理学的改变，如地形图紊乱(即，音调)和较差的频率调谐。工作记忆和注意力对精神分裂症知觉和生理变化的影响也将被研究。

DESCRIPTION (provided by applicant): Alterations in basic auditory perception in persons with schizophrenia have been noted for some time, but very little is known regarding how the changes in auditory behavioral function relate to underlying changes in anatomy and physiology. The relationship between poor auditory performance and the salient clinical symptoms of the disorder such as auditory hallucinations, if any, is also poorly understood. We are proposing an additional 5 years of funding to continue our efforts to characterize changes in the basic organizational principles of the auditory cortex in schizophrenia and their relationship to auditory psychophysics, clinical symptomatology and working memory. Magnetoencephalography (MEG), magnetic resonance imaging (MRI) and psychoacoustic methods will be employed to study these relationships in 80 people with schizophrenia and matched controls. We hypothesize that alterations in auditory physiology such as disturbed topographic mapping (i.e., tonotopy) and poorer frequency tuning underlie fundamental changes in auditory perceptual processes in schizophrenia. The impact of working memory and attention on perceptual and physiological changes in schizophrenia will also be examined.