Endocrinology-Reproductive Physiology Training Grant

说明(申请人提供)：从研究和健康的角度来看，需要更好地了解生殖机制和相关的健康问题，这是人口控制和间接消除贫困的一个主要因素。相反，生殖研究也可以为不孕不育提供解决方案。这些方面，以及成功完成妊娠到完全没有疾病，不仅与母婴健康直接相关，而且正常妊娠也是直到成年后长期健康的重要关键。威斯康星大学麦迪逊分校的内分泌学-生殖生理学(ERP)项目是一个长期专注于内分泌和生殖生理学的跨部门项目。我们的目标是提供博士后和博士后水平的培训，在生殖生理学和健康的前沿领域进行跨学科研究，并提供一个核心，通过这个核心，来自整个校园的教职员工和学生可以会面和协同。各种哺乳动物物种/细胞模型的研究涵盖神经内分泌和内分泌控制排卵、精子运动和受精、着床和胎盘形成以及子宫胎盘血流的控制/维持和足月及以后的正常发育。此外，还有几个教员直接研究发育和与怀孕有关的疾病，包括先兆子痫、青春期时机、更年期、宫内发育迟缓、多囊卵巢综合征的产前编程以及社会/压力对生育的抑制。最后，我们的许多教员在更一般的细胞信号领域处于领先地位，这与生殖生理学的各个方面高度相关，特别是与人类生殖。ERP项目目前有31名研究生，其中26名是博士生(国内18名，国际8名)。到目前为止，自1963年以来，该项目已有129名硕士研究生和156名博士生毕业，其中许多人后来在生殖生理学领域取得了突出的成就。这项提议的目的是为六个博士前职位寻求支持，为期五年。培训提案包括来自企业资源规划的18名培训员，企业资源规划也提供集中管理。这笔资金将支持该项目中近一半符合条件的学生。学员将成为博士候选人，在完成至少一年的培训后，每人将获得最长两年的支持。目前，博士生的平均毕业时间为5-6年。在各级寻求招募少数族裔参加企业资源规划方案，并通过企业资源规划方案/教员与威斯康星大学系统的协调行动提供便利。暑期学生奖学金、旅行基金和/或两年期弱势群体和少数群体奖学金也支持这些招聘努力。

DESCRIPTION (provided by applicant): From a research and health perspective, the need for a greater understanding of reproductive mechanisms and related health issues is a major factor in population control and, indirectly, the eradication of poverty. Conversely studies in reproduction can also provide solutions to infertility. These areas, as well as the successful completion of gestation to term free of disease are not only of immediate relevance to maternal and fetal health but normal gestation is also an important key to long term health far into adulthood, The Endocrinology-Reproductive Physiology (ERP) Program at the University of Wisconsin, Madison, is a longstanding interdepartmental program focused on the endocrinology and physiology of reproduction. Our aim is to provide training at the predoctoral and postdoctoral level in interdisciplinary research at the forefront of reproductive physiology and health, as well as provide a nucleus by which both faculty and students from across campus can meet and synergize. Research in a variety of mammalian species/cell models cover neuroendocrine and endocrine control of ovulation, sperm motility and fertilization, implantation and placentation as well as control/maintenance of uteroplacental blood flow and to normal development to term and beyond. In addition, there are several faculty directly investigating aspects of development as well as pregnancy related diseases, including preeclampsia, timing of puberty, menopause, intrauterine growth retardation, prenatal programming of polycystic ovarian syndrome and social/stress inhibition of fertility. Finally, many of our faculty lead the field in more general areas of cell signaling, which is highly relevant to all aspects of reproductive physiology, ing general, and human reproduction in particular. The ERP program currently has 31graduate students of which 26 are Ph.D. candidates (18 domestic, eight international). To date, since 1963, the program has graduated 129 M.S. and 156 Ph.D. candidates, many of who have gone on to prominent careers in reproductive physiology. The aim of this proposal is to seek support for six predoctoral positions for five years. The training proposal includes 18 trainers from the ERP, which also provides centralized administration. This funding will support almost half of the eligible students in the program. Trainees will be Ph.D. candidates and will be supported for up to two years each after they have completed at least one year of training. The average time to graduation for Ph.D. candidates is currently 5-6 years. The recruitment of minorities to the ERP program is sought at all levels and is facilitated by the coordinated actions of the ERP program/faculty together with the University of Wisconsin system. Summer Studentships, travel funds and/or two year Disadvantaged and Minority Fellowships also support these recruitment efforts.