Function and physiological role of inhibitory circuits in the amygdala
Function and physiological role of inhibitory circuits in the amygdala
批准号:
nhmrc : 1062183
负责人:
Prof Joseph Lynch
金额:
$49.44万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2018-12-31
中文摘要
杏仁核是大脑的一部分,负责将情感内容分配给我们的感官世界,杏仁核的功能障碍导致了许多与焦虑相关的疾病。许多抗焦虑药,如安定,作用于杏仁核中的受体。在这个项目中,我们将研究由抗焦虑药调节的杏仁核回路。这些研究将为理解焦虑障碍提供重要信息,并有助于开发治疗这些障碍的药物。
英文摘要
The amygdala is part of the brain that assigns emotional content to our sensory world and dysfunction of the amygdala is responsible for many anxiety-related disorders. Many anxiolytics, like valium, act on receptors in the amygdala. In this project we will study circuits in the amygdala that are modulated by anxiolytics. These studies will provide essential information in the understanding of anxiety disorders and help in developing drugs to treat these disorders.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The Effects of Human Epilepsy Mutations on Synaptic GABA-A Receptors Studied by Localization-based Superresolution Microscopy
-
批准号:nhmrc : 1147600
-
项目类别:Project Grants
-
资助金额:$34.95万
-
财政年份:2018
-
负责人:Prof Joseph Lynch
-
依托单位:
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
-
批准号:nhmrc : GNT1120947
-
项目类别:Project Grants
-
资助金额:$48.12万
-
财政年份:2017
-
负责人:Prof Joseph Lynch
-
依托单位:
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
-
批准号:nhmrc : 1120947
-
项目类别:Project Grants
-
资助金额:$32.84万
-
财政年份:2017
-
负责人:Prof Joseph Lynch
-
依托单位:
The role of zinc in synaptic transmission in the central nervous system
-
批准号:DP150102428
-
项目类别:Discovery Projects
-
资助金额:$25.52万
-
财政年份:2015
-
负责人:Prof Joseph Lynch
-
依托单位:
A novel mechanism for therapeutically modulating neurotransmitter-activated ion channels
-
批准号:nhmrc : 1060707
-
项目类别:Project Grants
-
资助金额:$44.51万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
Finding new ways to treat pain and anxiety disorders
-
批准号:nhmrc : GNT1058542
-
项目类别:Research Fellowships
-
资助金额:$72.76万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
Inhibitory neurotransmitter receptors as therapeutic targets for chronic pain and anxiety disorders
-
批准号:nhmrc : 1058542
-
项目类别:Research Fellowships
-
资助金额:$50.9万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
Inhibitory receptors in the amygdala
-
批准号:nhmrc : GNT1062183
-
项目类别:Project Grants
-
资助金额:$71.19万
-
财政年份:2014
-
负责人:Prof Joseph Lynch
-
依托单位:
The molecular basis of ionic selectivity in nicotinic-type ion channel receptors
-
批准号:DP130101702
-
项目类别:Discovery Projects
-
资助金额:$24.87万
-
财政年份:2013
-
负责人:Prof Joseph Lynch
-
依托单位:
New tools to activate and silence neural circuits
-
批准号:LP120100297
-
项目类别:Linkage Projects
-
资助金额:$32.92万
-
财政年份:2012
-
负责人:Prof Joseph Lynch
-
依托单位:
Understanding the mechanisms of GABA type-A receptor activation and drug modulation
-
批准号:DP120104373
-
项目类别:Discovery Projects
-
资助金额:$20.42万
-
财政年份:2012
-
负责人:Prof Joseph Lynch
-
依托单位:
Developing novel selective glycine receptor potentiators as a means to control pain.
-
批准号:nhmrc : 631448
-
项目类别:NHMRC Project Grants
-
资助金额:$36.85万
-
财政年份:2010
-
负责人:Prof Joseph Lynch
-
依托单位:
Activation mechanisms of Cys-loop ion channel receptors
-
批准号:DP1092582
-
项目类别:Discovery Projects
-
资助金额:$24.24万
-
财政年份:2010
-
负责人:Prof Joseph Lynch
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 569570
-
项目类别:NHMRC Research Fellowships
-
资助金额:$42.79万
-
财政年份:2009
-
负责人:Prof Joseph Lynch
-
依托单位:
Identification of novel therapeutic binding sites on glycine receptors by high throughput screening
-
批准号:nhmrc : 511169
-
项目类别:NHMRC Project Grants
-
资助金额:$36.14万
-
财政年份:2008
-
负责人:Prof Joseph Lynch
-
依托单位:
Therapeutic potential of glycine receptors in pain sensory pathways
-
批准号:nhmrc : 455931
-
项目类别:NHMRC Project Grants
-
资助金额:$19.49万
-
财政年份:2007
-
负责人:Prof Joseph Lynch
-
依托单位:
Molecular structure and function of the glycine receptor
-
批准号:DP0773954
-
项目类别:Discovery Projects
-
资助金额:$18.25万
-
财政年份:2007
-
负责人:Prof Joseph Lynch
-
依托单位:
Subunit stoichiometry and arrangement in the glycine receptor
-
批准号:DP0451836
-
项目类别:Discovery Projects
-
资助金额:$16.71万
-
财政年份:2004
-
负责人:Prof Joseph Lynch
-
依托单位:
Tropisetron: molecular mechanisms of action at the 5-HT3 receptor and the glycine receptor
-
批准号:nhmrc : 301053
-
项目类别:NHMRC Project Grants
-
资助金额:$24.79万
-
财政年份:2004
-
负责人:Prof Joseph Lynch
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 301023
-
项目类别:NHMRC Research Fellowships
-
资助金额:$38.92万
-
财政年份:2004
-
负责人:Prof Joseph Lynch
-
依托单位:
国内基金
海外基金
生理/病理应激差异化调控肝再生的“蓝斑—中缝”神经环路机制
-
批准号:82371517
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:杨立群
-
依托单位:
羊草子株出生、发育及成穗的生理与分子机制
-
批准号:31172259
-
项目类别:面上项目
-
资助金额:56.0万元
-
批准年份:2011
-
负责人:穆春生
-
依托单位: