Cell Migration Consortium

迁移是许多不同现象中的关键过程，包括胚胎发育、肿瘤形成和扩散、免疫应答期间的白细胞募集和伤口修复。阐明细胞迁移的潜在机制是一个巨大的智力挑战，因为它由几个复杂的分子和细胞过程组成，必须在空间和时间上协调。对细胞迁移过程的全面理解需要跨学科的方法，将不同的专家与技能相结合，为问题带来新颖的技术和知识解决方案。虽然移徙研究在调查人员和知识方面都在迅速增长，但进展很快就会受到一系列知识和技术障碍的限制。我们建议利用大规模合作项目倡议来应对机遇，克服目前阻碍细胞迁移进展的障碍所带来的挑战。该倡议的核心是计划创建一个高度互动的多学科研究联盟，由在粘附和细胞迁移领域取得杰出成就的核心研究人员组成。该倡议的核心是计划创建一个高度互动的多学科研究联盟，由在粘附和细胞迁移领域具有杰出成就记录的核心研究者组成，合作者带来了其他学科所需的技术和专业知识，例如，数学建模结构，成像，生物材料，并支持他们的专业知识应用于移民问题，最后顾问，谁提供的建议和信息的关键领域的研究需要加强该联盟的目标。该联盟的一个主要目标是开发克服细胞迁移研究面临的障碍所需的新技术。这将通过在核心研究者的指导下支持五项创新的发展性研究计划（指定为“发展核心”）来实现。蛋白质组学和基因组学核心将确定有助于细胞迁移的基因和基因产物的完整库;结构核心将在宏观和原子水平上分析大型超分子粘附组装体的组织，信号核心将寻求新的方法来检测信号分子在空间和时间上的激活状态;转基因和敲除核心将创建具有遗传改变的迁移机制的细胞和小鼠模型; 2建模核心将开发组件迁移过程和通过网络的信号转导的定量分析和建模机制。此外，该联盟将通过关键的支持设施支持关键技术和技术开发，包括质谱分析、生物材料、蛋白质生产和分析以及细胞成像。最后，联合会将提供基础设施，支持联合会的行政需要，通过视频电信、生物信息学、数据和信息传播以及联合会所有项目共有的技术资源促进互动。

Migration is a pivotal process in many diverse phenomena including embryonic development, tumor formation and spread, leukocyte recruitment during immune responses, and wound repair. Elucidating the mechanisms underlying cell migration presents a formidable intellectual challenge since it is comprised of several complex molecular and cellular processes that must be coordinated in both space and time. A full comprehension of the process of cell migration requires an interdisciplinary approach that combines diverse specialists with skills to bring novel technical and intellectual solutions to the problem. While migration research is undergoing rapid growth in both investigators and knowledge, progress will soon by restrained by an approaching set of intellectual and technological barriers. We propose using the Large Scale Cooperative Project initiative to address the opportunities and overcome the challenges posed by the present barriers to progress in outstanding cell migration. At the center of the initiative is a plan to create a highly interactive, multi-disciplinary research Consortium comprised of Core Investigators with outstanding records of accomplishment in the field of adhesion and cell migration. At the center of the initiative is a plan to create a highly interactive, multi-disciplinary research Consortium comprised of Core Investigators with outstanding records of accomplishment in the field of adhesion and cell migration, collaborators who bring needed technology and expertise from other disciplines, e.g., mathematical modeling structure, imaging, biomaterials, and are supported to apply their expertise to the migration problem, and finally consultants, who provide advice and information on critical areas of research need to enhance the goals of the Consortium. A major objective of the Consortium is to develop new technologies that are needed to over come the barriers that face cell migration research. This will be accomplished by supporting five innovative, developmental research initiatives (designated "Development Cores") under the direction of the Core Investigators. The Proteomics and Genomics Core will determine the complete repertoire of genes and gene products that contribute to cell migration; the Structure Core will analyze the organization of large, supramolecular adhesive assemblies at the macro and atomic level, the Signaling Core will seek novel approaches to the detection of activated states of signaling molecules in space and time; the Transgenic and Knockout Core will create cells and mouse models with genetically altered migration machinery; the Modeling Core will develop quantitative assays and modeling mechanisms of component migratory processes and signal transduction through networks. In addition, the Consortium will support critical technologies and technology development through key Support Facilities, including mass spectrometry, biomaterials, protein production and analysis and cell imaging. Finally, the Consortium will provide infrastructure to support the administrative needs of the Consortium, promote interaction through video telecommunications, bioinformatics, data and information dissemination and the technology resources that are common to all of the Consortium projects.