NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)

这是国家阿尔茨海默氏症协调中心（NACC）的竞争延续应用程序。之间 大约在1984年和1997年，没有集中收集29个阿尔茨海默病中心（ADC）的数据。 国家老龄化研究所。大约在1997年建立了一个临时数据中心和一个最小数据集， NIA为阿尔茨海默病数据协调中心发布RFA。自从接收临时中心 最小数据集（MDS），NACC已成功地完善和扩大了整个数据库，减少了缺失数据， 提高了数据有效性，扩大了神经病理学数据，增加了中心范围的数据调查，并增加了 通过使用基于网络的数据访问和输入来访问数据。为使用提供的能力 在建立NACC之前，ADC尚未经历合并ADC数据。超过6万人 受试者，这是目前最大的阿尔茨海默氏症和相关疾病数据库有史以来在美国组装。 NACC还负责增加ADC之间的合作，不仅通过使用 除了通过促进专家发起的合作项目和提供统计数据， 为发展合作委员会和合作项目提供方法和数据库管理咨询。未来 在赠款周期内，NACC将继续扩大这些努力。统一数据集（UDS）现在已被授权用于 NIA在所有ADC中使用。NACC将建立一个数据库结构来实施UDS，收集数据并将其整合 与现有数据无缝连接。NACC将开发一种获取转诊来源和选择方法数据的方法 所有新的UDS注册者。这些数据将有助于描述和增加外部有效性的分析，使用 数据库，并将成为ADC为其病例选择最具可比性的对照的基础。NACC将继续 它成功的合作项目计划，也将鼓励从初级的小型二级数据分析研究 investigators. NACC将继续提供设计和分析咨询服务，并加大力度，加强沟通 并通过NACC网站进行合作。NACC还将进行自己的数据分析， 与ADC需求相关的方法研究和一般研究。最后，NACC将继续其 行政协调活动，以促进发展局局长和核心领导人的会议。

This is the Competing Continuation application of the National Alzheimer's Coordinating Center (NACC). Between about 1984 and 1997, no data were centrally collected for the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging. Establishment of an interim data center and a Minimum Data Set in about 1997 led to the NIA issuance of an RFA for an Alzheimer's Disease Data Coordinating Center. Since receiving the interim center Minimum Data Set (MDS), NACC has successfully refined and expanded the overall database, reduced missing data, increased data validity, expanded neuropathological data, added Center-wide data surveys, and increased accessibility to the data through the use of web-based data access and entry. The capabilities provided for use of combined ADC data have not been experienced by the ADCs prior to the establishment of NACC. With over 60,000 subjects, this is currently the largest Alzheimer's and related disorders database ever assembled in the U.S. NACC was additionally charged with increasing collaboration between the ADCs, not only through the use of the MDS but also through the promotion of investigator-initiated collaborative projects and the provision of statistical, methodological and database management consulting to the ADCs and for the collaborative projects. In the next grant cycle, NACC will continue to expand on these efforts. The Uniform Data Set (UDS) has now been mandated for use in all ADCs by NIA. NACC will build a database structure to implement the UDS, collect the data and integrate it seamlessly with the existing data. NACC will develop a means of capturing referral source and selection method data for all new UDS enrollees. These data will help describe and increase the external validity of analyses which use the database and will form the basis for ADCs to select the most comparable controls for their cases. NACC wilt continue its successful collaborative project program and will also encourage small secondary data analysis studies from junior investigators. NACC will continue design and analysis consulting, and expand its efforts to increase communication and collaboration through the NACC web site. NACC will also conduct its own data analyses and develop methodological research relevant to the needs of the ADCs and research in general. Finally, NACC will continue its administrative coordinating activities to facilitate meetings of the ADC Directors and Core Leaders.