Developmental Biology Training Program

描述（申请人提供）：近年来，发育生物学领域在很大程度上是通过生物科学中许多学科的整合而成熟的，包括遗传学、细胞生物学、胚胎学、生理学、分子生物学、生物化学和进化生物学。明尼苏达大学发育生物学的研究重点是由发育生物学中心提供的，该中心设在遗传、细胞生物学和发育系，这是医学院和生物科学学院的一个全大学部门。发育生物学中心的成员来自大学内许多其他院系，包括神经科学、儿科、植物生物学、检验医学和数学。发育生物学中心每年举办一次受欢迎的明尼苏达大学发育生物学研讨会，每周和每月举办一系列发育生物学研究研讨会，研究生和博士后研究人员在那里展示他们的工作，并促进明尼苏达大学发育生物学家之间的互动和合作。培训师都是该中心的成员，他们在发育生物学的不同领域工作，使用许多不同的模式生物，包括小鼠、斑马鱼、爪蟾、果蝇、秀丽隐杆线虫、盘基骨菌和拟南芥。培养发育生物学学员的主要研究生项目是分子、细胞、发育生物学和遗传学（MCDB&G）研究生项目。本课程围绕实验室技术、分子生物学、遗传学、细胞生物学、发育生物学、文献分析和不同系统的实验室旋转等核心研究生课程展开。培训师有很强的研究项目和良好的记录，致力于研究生和博士后培训。五名博士预科生将被选为培训资助对象，他们主要来自mcdb和g的研究生，但也可能来自其他研究生项目，如神经科学和生物化学、分子生物学和生物物理学。受训者在培训人员的实验室开始论文工作后，将得到一至三年的支助。培训实验室和核心设施设备齐全。对发展的理解是许多现代医学的基础，最终将有助于深入了解从先天性先天缺陷到衰老等许多重大公共卫生问题的原因和可能的治疗方法。

DESCRIPTION (provided by applicant): The field of developmental biology has matured in recent years, largely through the integration of many disciplines within biological sciences, including genetics, cell biology, embryology, physiology, molecular biology, biochemistry, and evolutionary biology. The focus for developmental biology at the University of Minnesota is provided by the Developmental Biology Center, which is based in the Department of Genetics, Cell Biology, and Development - an all-University department within both the School of Medicine and the College of Biological Sciences. The Developmental Biology Center embraces members from many other departments within the University including Neuroscience, Pediatrics, Plant Biology, Laboratory Medicine, and Mathematics. The Developmental Biology Center organizes a popular annual University of Minnesota Developmental Biology Symposium, runs a weekly and monthly series of research seminars in developmental biology, where graduate students and postdoctoral researchers present their work, and promotes interactions and collaborations among developmental biologists at the University of Minnesota. The trainers are all members of the Center and work in diverse areas of developmental biology using many different model organisms, including mice, zebrafish, Xenopus, Drosophila, C. elegans, Dictyostelium, and Arabidopsis. The principal graduate program for developmental biology trainees is the Molecular, Cellular, Developmental Biology, and Genetics (MCDB&G) graduate program. This program is built around strong core graduate courses in laboratory techniques, molecular biology, genetics, cell biology, developmental biology, literature analysis, and laboratory rotations in diverse systems. The trainers have strong research programs and strong records of commitment to graduate and postdoctoral training. Five predoctoral trainees will be chosen for training grant support, largely from the pool of graduate students in MCDB&G but possibly also from other graduate programs, such as Neuroscience and Biochemistry, Molecular Biology and Biophysics. Trainees will be supported for one to three years, after they have begun their thesis work in the laboratories of the trainers. The training laboratories and core facilities are all well equipped. An understanding of development is fundamental to much of modern medicine and will ultimately contribute key insights into the causes of, and possible therapies for, many major public health problems ranging from congenital birth defects to senescence.