BRAIN DISTRIBUTION OF BETA AMYLOID IN HUMAN AND NONHUMAN PRIMATES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。β淀粉样蛋白是一种随着年龄增长在人类大脑皮层中积累的蛋白质。β淀粉样蛋白是有毒的，它的毒性被认为是阿尔茨海默病-S病的病理性神经退行性变的始作俑者。β淀粉样蛋白也在非人类灵长类动物中积累，但它们不会患上阿尔茨海默病？S病。即使是像黑猩猩这样可以活到60岁或更长时间，并能表现出类似人类的淀粉样堆积的类人猿物种，也没有发展出阿尔茨海默氏症的其他特征？S病理。我们正在调查人类β淀粉样蛋白是什么导致它对我们物种如此有毒。具体地说，我们正在比较人类和非人类灵长类动物中存在的β淀粉样多肽的数量和不同形式，并比较这种多肽在这些不同物种的脑细胞中的处理和运输方式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Beta amyloid is a protein that accumulates with age in human cerebral cortex. Beta amyloid is toxic, and its toxicity is thought to be the initiator of the pathological neurodegeneration that characterizes Alzheimer?s disease. Beta amyloid also accumulates in nonhuman primates, but they do not get Alzheimer?s disease. Even great ape species, such as chimpanzees, which can live to 60 years of age or more and can display human-like amyloid accumulations, do not develop the other features of Alzheimer?s pathology. We are investigating what it is about human beta amyloid that renders it so toxic in our species. Specifically, we are comparing the amount and different forms of the beta amyloid peptide that are present in humans and nonhuman primates, and are comparing how the peptide is processed and transported in the brain cells of these different species.