NEUROSCIENCE CENTER FOR INGESTIVE BEHAVIOR

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。吞咽行为是诱发多种疾病的主要因素，但导致吞咽行为的神经体液机制还不是很清楚。对这些机制的了解可能会导致控制作为特定疾病危险因素的摄食行为的新策略。这是一个涉及几个机构的五个组成部分的多调查员计划。其目的是为了更好地理解以下内容：1.小鼠模型中摄食行为的神经体液组织。2.黑猩猩模型的血压盐敏感性。3.人类和狒狒模型中的食欲机制。4.狒狒模型中盐和水摄入量的神经体液控制。5.狒狒模型中的BRAN受体机制。项目2和4是在中华人民共和国进行的。项目2的初步结果支持这样的假设，即饮食中盐的增加会在9个月内导致血压显著上升，当动物回到低盐饮食时，这种影响是可逆的。项目4的初步结果支持这样的假设，即与肾脏盐和水稳态有关的激素因素在调节灵长类动物的盐摄取行为方面起着重要作用。预计这些结果将提供足够的数据，使未来能够研究控制食盐量的生理机制以及控制这些机制的潜在遗传因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ingestive behavior is a major factor in predisposing to a variety of diseases, but the neurohumoral mechanisms responsible for ingestive behavior are not well understood. An understanding of those mechanisms may lead to new strategies for controlling ingestive behaviors that are risk factors for specific diseases. This is a five component multi-investigator program that involves several institutions. The objectives are to develop a better understanding of the following 1. Neurohumoral organization of ingestive behavior in a mouse model. 2. Salt-sensitivity of blood pressure in a chimpanzee model. 3. Appetite mechanisms in humans and in a baboon model. 4. Neurohumoral control of salt and water intake in a baboon model. 5. Bran receptor mechanisms in a baboon model. Projects 2 and 4 are conducted at the SRPRC. The preliminary results for Project 2 support the hypothesis that an increase in dietary salt causes a significant elevation of blood pressure within 9 months, and the effect is reversible when the animals are returned to a low salt diet. Preliminary results for Project 4 support the hypothesis that hormonal factors related to renal salt and water homeostasis are important in regulating salt intake behavior in primates. It is expected that the results will provide sufficient date to enable future research on the physiological mechanisms that control salt appetite and the underlying genetic factors that control these mechanisms.