HBSAG + HBSIC-1018 VACCINE INJECTION ROUTE COMPARISON

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。乙肝表面免疫球蛋白制剂由免疫刺激DNA序列(ISS)与乙肝病毒表面抗原(乙肝表面抗原-1018)结合而成。本实验的目的是评价肌肉注射(IM)和皮下注射(SC)两种途径对狒狒对乙肝表面抗原+乙肝表面抗原-1018制剂免疫应答的影响。一种乙肝表面抗原-1018 ISS结合物之前已经在狒狒身上进行了测试，当通过肌肉注射给药时，它显示出对乙肝表面抗原的强烈抗体反应。然而，乙肝表面抗原-1018 ISS制剂从未通过皮下途径在狒狒身上进行过测试。本实验将有助于确定免疫途径是否能增强狒狒对乙肝表面抗原的体液和细胞免疫应答。这项研究可能对社会有益，因为它将有助于开发新的/改进的乙肝疫苗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HBsIC formulations consist of immunostimulatory DNA sequences (ISS) conjugated to hepatitis B virus surface antigen (HBsIC-1018). The objective of this experiment is to assess the effect of injection route ¿ intramuscular (IM) and subcutaneous administration (SC) - on the immune response of baboons to HBsAg + HBsIC-1018 formulation. An HBsAg-1018 ISS conjugate has been previously tested in baboons and it showed strong antibody responses to HBsAg when administered via intramuscular injection. However HBsAg-1018 ISS formulation has never been tested in baboons via the subcutaneous route. This experiment will help determine if immunization route can enhance the humoral and cell mediated immune responses of baboons to HBsAg. This study may be beneficial to society since it will help in the development of a new / improved HBV vaccine.