Harnessing the Innate Immune System to Target Cancer: A Novel Immunotherapeutic Strategy for Solid Tumours

尽管最近癌症治疗有所改善，但癌症仍然是世界范围内死亡的主要原因。这个项目建立在我们最近的研究基础上，该研究展示了一种新的机制，通过这种机制可以“启动”患者自身的免疫系统，从而产生有效的抗癌反应。特别是，我们寻求利用我们的商业合作伙伴开发的靶向c3ar的反义寡核苷酸来治疗对当前免疫治疗方法无反应的晚期癌症。

Despite recent improvements in cancer treatments, cancer remains a major cause of death world-wide. This project builds on our recent research demonstrating a novel mechanism by which to 'kick-start' the patient's own immune system to mount an effective anti-cancer response. Specifically we seek to utilise C3aR-targeting antisense oligonucleotides developed by our commercial partner for treatment of advanced cancers that are unresponsive to current immunotherapeutic approaches.