ADCS/NIA PROTOCOL ACD-015: SIMVASTATIN TO SLOW THE PROGRESSION OF ALZHEIMER'S

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。来自动物模型和细胞培养系统的实验室研究、观察性流行病学研究和小型临床试验的令人信服的证据表明，降低胆固醇可能会减少阿尔茨海默病(AD)的病理。这些研究表明，胆固醇水平升高可能与淀粉样蛋白沉积和认知功能有关，降低这些水平可能会减少淀粉样蛋白并导致认知益处。辛伐他汀是一种HMG-CoA还原酶抑制剂。在患有冠心病和高胆固醇血症的患者中，研究表明，它可以降低1)总死亡率，2)非致命性心肌梗死，3)接受心肌血管重建术，4)中风或短暂性脑缺血发作的风险。这项研究背后的假设是，辛伐他汀将显著减缓阿尔茨海默病的临床进展，并将在日常生活活动、精神和行为症状、生活质量和经济指标方面显示出比安慰剂有利的效果。这项研究的人群将是400名没有高胆固醇血症的AD患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is compelling evidence from laboratory research in animal model and cell culture systems, observational epidemiological studies, and small clinical trials that lowering cholesterol may reduce the pathology of Alzheimer's Disease (AD). These studies indicate that elevated cholesterol levels may be related to amyloid deposition and cognitive function and that lowering these levels may reduce amyloid and lead to cognitive benefit. Simvastatin is an HMG-CoA reductase inhibitor. In patients with coronary heart disease and hypercholesterolemia, it is indicated to reduce the risk 1) of total mortality by reducing coronary death, 2) of non-fatal myocardial infarction, 3) for undergoing myocardial revascularization procedures and 4) of stroke or transient ischemic attack. The hypothesis behind this study is that simvastatin will significantly reduce the clinical progression of AD and will show beneficial effects over placebo on measures of activities of daily living, psychiatric and behavioral symptoms, quality of life and economic measures. The population for this study will be 400 subjects with AD who do not have hypercholesterolemia.