ASSESSING ENERGY NEEDS OF OVERWEIGHT AND OBESE INDIVIDUALS: A COMPARISON OF ME

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究的主要目的是比较不同方法预测和测量的静息能量消耗(REE)。研究AOM#1：比较超重和肥胖者静息能量消耗的三种方法：1)预测方程(Harris Benedict方程(HBE))，2)传统间接量热法(Vmax 29N)测量呼吸商(RQ)，3)手持设备(MedGemTM)固定RQ测定REE。研究目标2：评估参与者对不同稀土元素测定方法的偏好。为了检验偏好有显著差异的假设，我们将让参与者1)使用测量RQ的传统间接量热法(Vmax 29N)，以及2)使用口罩使用固定RQ的手持式设备(MedGemTM)来确定偏好。研究目标3：比较身体成分，特别是瘦体重和稀土元素。研究目标#4：描述与代谢综合征相关的受试者群体以及代谢综合征的不同成分与稀土元素的关系。代谢综合征是指存在3种或3种以上与体重有关的异常：男性腰围102厘米(40英寸)，女性88厘米(35英寸)，甘油三酯150 mg/dl，高密度脂蛋白40 mg/dl，女性50 mg/dl，血压130/85 mm Hg(收缩压和/或舒张压升高)，和/或空腹血糖110 mg/dl。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to compare predicted and measured resting energy expenditure (REe) using different methods. Study Aom #1: To compare resting energy expenditure in overweight and obese individuals determined by three methods: 1) prediction equation (Harris Benedict Equation (HBE)), 2) traditional indirect calorimetry (Vmax 29N) with measured respiratory quotient (RQ), and 3) handheld device (MedGemTM) with fixed RQ to determine REE. Study Aim #2: To assess participant preference for different methods of determining REE. In order to test the hypothesis that there is a significant difference in preference, we will have the participants rate 1) traditional indirect calorimetry (Vmax 29N) with measured RQ and 2) hand-held device (MedGemTM) with fixed RQ using a mouthpiece to determine preference. Study Aim #3: To compare body composition, specifically lean body mass, with REE. Study Aim #4: To describe the subject population relative to the metabolic syndrome and the associaton of different components of the metabolic syndrome with REE. The metabolic syndrome is defined when 3 or more of the following abnormalities related to weight are present: Waist circumference >102 cm (40in) in men and >88 (35 in) in women, triglycerides (TG) > 150 mg/dl, high-density lipoprotein (HDL) <40 mg/dl in men and <50 mg/dl in women, blood pressure >130/85 mm Hg (elevation of systolic and/or diastolic blood pressure), and/or fasting glucose >110 mg/dl.