ICG

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究正在调查与改善美国（华盛顿特区、俄亥俄州克利夫兰）和尼日利亚（伊巴丹）基因研究中的知情同意有关的问题。这将通过现有的研究来完成，这些研究将检查华盛顿特区大都市区一组非裔美国人的高血压遗传流行病学。具体目标是：(i)开发、测试和实施录像教育干预，以改善高血压和乳腺癌遗传流行病学研究的知情同意，（ii）进行随机试验，以测试录像教育干预对两个结果的影响：A.了解研究目标和b.参与知情同意讨论，（三）审查关于基因研究对个人健康以及个人和群体认同的影响的看法，并确定它们对个人参与基因研究的意愿和动机的影响，（四）提出建议，改进遗传流行病学研究的知情同意程序，以确保这些程序在文化上是适当的；最大限度地为少数民族提供信息和保护。参与者将被随机分为两组：(1)传统的同意方式；(2)录像的教育干预与通常的同意程序。观察性检查表将用于评估参与者在知情同意讨论中的参与情况。随后将对参与者进行随访访谈，一次在同意讨论后一周内，另一次在同意讨论后6-9个月。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study is investigating issues related to improving informed consent in genetic research in the United States (Washington DC, Cleveland OH) and Nigeria (Ibadan). This will be done through existing studies examining the genetic epidemiology of hypertension in a cohort of African Americans in the Washington DC metropolitan area. The specific goals are to: (i) develop, test and implement a videotaped educational intervention to improve informed consent for genetic epidemiological research on hypertension and breast cancer, (ii) conduct a randomized trial to test the effect of the videotaped educational intervention on two outcomes: a. comprehension of research goals and b. participation during the informed consent discussion, (iii) examine beliefs about the implications of genetic research for personal health and individual and group identity, and determine their influence on individual's willingness and motive to participate in genetic research, (iv) develop recommendations to improve informed consent procedures for genetic epidemiological research to ensure that they are culturally appropriate, maximally informative and protective for ethnic populations. Participants will be randomized into one of two groups: (1) traditional approach to consent and (2) a videotaped educational intervention with the usual consent procedures. An observational checklist will be used to assess participants' participation in the informed consent discussion. Follow up interviews will then be done with pariticpants, one within one week of the consent discussion and the other 6-9 months afterwards.