CHILDREN'S HEALTH AND NATURAL GROWTH EVALUATION STUDY (CHANGES)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。儿童健康和自然生长评估研究(CHANGES)考察了已经超重的年轻人从童年中期开始积累的全身脂肪和内脏脂肪(位于腹部器官周围的脂肪)的自然时间进程。内脏脂肪被认为是成年人体内脂肪分布中最有害的类型，但尚不清楚儿童如何、何时或为什么积累这种类型的脂肪。本研究旨在确定腹内脂肪积累相对较高和较低的特定发育期，并评估潜在的激素(如瘦素、胰岛素)和行为(如体力活动、饮食成分)因素和儿童体内脂肪分布变化的后果。这是一项为期两年的前瞻性研究，在36名8岁开始参与研究的超重儿童中进行。评估每六个月进行一次，并与体脂总量、体脂分布、体重和发育相关激素以及体重相关行为的测量一致。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Child Health and Natural Growth Evaluation Study (CHANGES) examines the natural time course of total body fat and visceral fat (fat located around the organs within the abdominal cavity) accumulation through middle childhood among already overweight youth. Visceral fat is considered the most harmful type of body fat distribution in adults, but it is unclear how, when, or why children accumulate this type of fat. This study seeks to identify specific developmental periods of relatively high and low intra-abdominal fat accumulation, and to evaluate potential hormonal (e.g., leptin, insulin) and behavioral (e.g., physical activity, dietary components) factors and consequences of children's changing body fat distribution. This is a 2-year prospective study being conducted among 36 overweight children who started participation at age 8. Assessments occur every six months and consistent of measurement of total body fat, body fat distribution, weight- and development-related hormones, and weight-related behaviors.