PAYING THE SLEEP DEBT TO IMPROVE GLUCOSE TOLERANCE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。睡眠不足对代谢功能的负面影响最近已经得到证实。在健康男性中，限制睡眠（每晚4小时）1周显著降低葡萄糖耐量。延长1周的睡眠时间可以完全恢复。拟议的研究将验证糖耐量受损的IGT或糖尿病（DM2）患者支付睡眠债务将改善糖耐量的假设。习惯性就寝时间<7小时/晚的IGT或DM2患者将在基线和干预（延长就寝时间3小时/晚并指导睡眠卫生）或不干预2周后在CRC中进行研究。主要终点将是口服和静脉葡萄糖耐量的测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The negative impact of sleep loss on metabolic function has recently been demonstrated. In healthy men, restricted sleep (4 hrs/night) for 1 week markedly diminished glucose tolerance. Extending sleep for 1 week allowd for full recovery. The proposed studies will test the hypothesis that paying the sleep debt in patients with impaired glucose tolerance IGT or diabetes (DM2) will improve glucose tolerance. Patients with IGT or DM2 who have habitual bedtimes <7 hrs/night will be studied in the CRC at baseline and after a 2-week period with intervention (bedtimes extended by 3 hrs/night and instruction in sleep hygiene) or no intervention. Primary endpoints will be measures of oral and intravenous glucose tolerance.