IMPACT OF A SLEEP DEBT IN MID & OLDER AGED ADULTS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。先前的研究表明，年轻人的睡眠缩短会导致葡萄糖耐量受损、皮质醇水平升高、瘦素水平降低和心脏交感神经活动增加。我们将以下列方式检查这些相同的标记：1.研究青年、中年和老年人经常性部分睡眠丧失的影响。睡眠将被限制在4小时。2.测试是否延长睡眠时间恢复睡眠将逆转由睡眠限制引起的变化。睡眠时间将延长至12小时。3.检查在12小时就寝时间的一周内获得的睡眠恢复总量的年龄和性别相关差异。4.测试睡眠能力是否部分取决于慢波睡眠和慢波活动的基线水平。6.通过比较变化的幅度与睡眠债的幅度来检查睡眠能力是否与睡眠需求有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous work has demonstrated that sleep curtailment in young adults results in impaired glucose tolerance, elevated cortisol levels, reduced leptin levels, and increased cardiac sympathetic activity. We will examine these same markers in the following ways: 1. Examining the impact of recurrent partial sleep loss in young, middle-aged and older adults. Sleep will be restricted to 4 hrs. 2. Testing whether extending bedtimes for sleep recovery will reverse the alterations resulting from sleep restriction. Sleep will be extended to 12 hours. 3. Examining age and gender related differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes. 4. Testing whether sleep capacity is partly determine by baseline levels of slow-wave sleep and slow-wave activity. 6. Examining whether sleep capacity is related to sleep need, by comparing the magnitude of changes to the magnitude of sleep debt.