T1DGC THE TYPE 1 DIABETES GENETICS CONSORTIUM NORTH AMERICAN REGIONAL NETWORK

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。芝加哥大学将为NIH资助的合作项目“1型糖尿病遗传学联盟”（T1 DGC）建立一个招募网站。该联盟的目标是组织国际努力，以确定决定个人1型糖尿病风险的基因。由于缺乏足够的临床和遗传资源，世界范围内实现这一目标的进展受到限制。在一项试点研究中，已经证明了更大的家族集合在绘制1型糖尿病基因图谱方面的作用。创建一个资源基础的良好特征的家庭从多个种族群体将有利于本地化和1型糖尿病基因的特点，决定疾病的风险。将对适当功率的数据集进行统计遗传分析，以确定与1型糖尿病相关的区域，并确定这些相关区域如何发挥作用和潜在相互作用。在这些联盟资源的基础上，联盟的成员和合作者将进行定位克隆，以确定决定易感性或保护的单个基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The University of Chicago will establish a recruitment site for an NIH-funded collaboration, the "Type 1 Diabetes Genetics Consortium" (T1DGC). The goal of the Consortium is to organize international efforts to identify genes that determine an individual's risk of type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The power of larger collections of families to map type 1 diabetes genes has been demonstrated in a pilot study. The creation of a resource base of well-characterized families from multiple ethnic groups will facilitate the localization and characterization of type 1 diabetes genes that determine disease risk. Statistical genetic analyses will be performed on appropriately powered data sets to identify regions linked to type 1 diabetes and determine how these linked regions act and potentially interact. Building upon these Consortium resources, members and collaborators of the Consortium will undertake positional cloning to identify individual genes that determine susceptibility or protection.