SLEEP LOSS AND CIRCADIAN DISRUPTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。工作时间的延长几乎总是会导致睡眠时间的减少。产生最短睡眠时间的工作时间表是夜班工人的工作时间表。除了睡眠不足，轮班工作也会导致昼夜节律的慢性适应不良。本提案的总体目标是检验这一假设，即在延长的工作时间表期间发生的睡眠不足可能会导致不良的健康后果，并且昼夜节律适应不良（独立于睡眠不足）也会对健康产生负面影响。我们建议使用两个实验方案，涉及8天的就寝时间缩短。第一个协议模拟了一个有规律的延长白天时间和限制夜间睡眠的时间表。第二个协议模拟了白天工作和夜间工作之间的工作时间表。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extended work schedules almost invariably result in reduced time for sleep. Work schedules that produce the shortest sleep times are those of night workers. In addition to sleep loss, shift work also results in chronic maldaptation of circadian rhythms. The overall goal of the present proposal is to test the hypothesis that sleep loss occurs during extended work schedules may results in adverse health consequences and that circadian maladaptation, independently of sleep loss, has also negative health consequences. We propose to use two experimental protocol involving 8 days of bedtime curtailment. The first protocol simulates a schedule of regular extended daytime hours with restricted nighttime sleep. The second protocol simulates a work schedule altering between day work and night work.