OBESITY/INSULIN RESISTANCE, VITAMIN C AND ENDOTHELIN-1

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。随着身体肥胖的增加，动脉“血管舒张”（或增大尺寸）的能力降低，这可能会增加与超重或肥胖相关的心血管疾病的风险。导致血管扩张剂能力降低的潜在机制之一是血管收缩的趋势增加（尺寸减小和/或对血管扩张的抵抗），这是由一种叫做内皮素-1的物质介导的。ET-1的产生和活性升高与心血管疾病的风险增加有关。这项研究的另一个目的是比较补充维生素C（一种安全而廉价的治疗方法）和定期有氧运动在减少动脉血管收缩倾向方面的效果

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With an increase in body fatness the ability of arteries to "vasodilate"(or increase in size) is reduced which may contribute to an increased risk of cardiovascular diseases associated with being overweight or obese. One of the potential mechanisms that may contribute to this reduced vasodilator capacity is an increased tendency towards vasoconstriction (decrease in size and/or resistance to vasodilation), mediated by a substance called endothelin-1. Elevations in ET-1 production and activity has been linked to an increased risk of cardiovascular disease. An additional aim of this study is to compare the effects of vitamin C supplementation, a safe and inexpensive treatment, and regular aerobic exercise in reducing the tendency of arteries to vasoconstr