AGING, EXERCISE AND ENDOTHELIN-1 VASOCONSTRICTOR TONE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。随着年龄的增长，动脉血管扩张的能力（尺寸增加以携带更多血液）下降。这与心脏病和中风的风险增加有关。这一下降的原因尚不清楚。以往的研究表明，有规律的有氧运动可以提高动脉血管扩张的能力。这项研究的目的是确定随着年龄的增长，动脉是否更容易发生血管收缩（尺寸减小），以及定期有氧运动是否会降低血管收缩的趋势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With advancing the age the ability of arteries to vasodilate (increase in size to carry more blood) decreases. This is associated with an increased risk of heart attach and stroke. The reasons for this decline are not well understood. Previous studies have shown that regular aerobic exercise can improve the abilities of arteries to vasodilate. The purpose of this study is to determine whether with advancing age arteries are more prone to vasoconstrict (decrease in size) and whether regular aerobic exercise reduces this tendency to vasoconstrict.