MT COBRE: CORE FACILITY DEVELOPMENT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。COBRE项目的一个主要目标是通过开发核心设施，增加研究人员使用最先进设备的机会，从而提高研究竞争力。正如我们的组织结构图所述，调查人员可以访问校园内六个急需的核心研究设施（crf）。其中四个CRFs由COBRE CSFN直接资助：质谱学和蛋白质组学，分子组织学和荧光成像，分子计算和建模，以及生物光谱学。重要的是，这些crf不仅得到了目前COBRE奖的支持，还得到了大学研究办公室和蒙大拿州的匹配资金，以及美国国立卫生研究院和美国国家科学基金会授予UM的资助。CRFs继续发展，并按计划不仅加强了个别项目，而且促进了合作。从这些核心中产生的项目已开始出版出版物，并将作为关键资源列入CSFN研究人员资助的若干R01申请以及提交的申请中。在这方面应该指出的是，在几乎每一个情况下，提交的赠款（得分和未得分）的RO1审查表继续将研究环境描述为非常支持拟议项目。在过去一年的活动中，特别值得注意的是制定了一项全校范围的计划，以支持研究基金。UM的研究人员和管理人员都有一个明确的共识，即所有核心的长期运作对大学（和COBRE）在生物医学研究领域建立有竞争力的项目的使命至关重要。人们也很容易认识到，校园里的研究人员的临界数量不太可能增长到这样的程度，即大多数crf可以完全依靠用户费用来支持。因此，持续的支持将取决于多方面的战略，包括：基础设施拨款（例如，COBRE, EPSCoR），国家匹配，个人ro1，多研究者拨款，以及大学研究副校长办公室。管理计划也已到位。四名CRF主任组成一个指导委员会和咨询小组，其具体目标包括：(a) CSFN研究圆桌会议；(b)预算；(c) CSFN报告职能；(d)整体设施整合和管理。除了四位董事外，COBRE PD （R Bridges）、研究副总裁（D Dwyer）、COBRE PD助理（K Stewart）和两名外部顾问成员将在指导委员会（季度会议）中任职，负责财务、员工、报告和运营。该委员会最终将扩大到包括校园内的其他核心设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major goal of the COBRE project is to enhance research competitiveness by increasing the access investigators have to state-of-the-art equipment through the development of core facilities. As outlined on our organizational chart, investigators have access to six critically needed Core Research Facilities (CRFs) on campus. Four of these CRFs are directly funded by the COBRE CSFN: Mass Spectroscopy and Proteomics, Molecular Histology and Fluorescence Imaging, Molecular Computation and Modeling, and BioSpectroscopy. Importantly, these CRFs are supported not only by the present COBRE award, but also by the University Research Office and State of Montana match funding, as well as by NIH and NSF grants awarded to UM. The CRFs have continued to develop and, as planned, have served not only to enhance individual projects but also to promote collaborations. Projects emerging from these cores have begun to produce publications and to be included as a critical resource in a number of funded R01 applications by CSFN investigators as well as in submitted applications. It should be noted in this regard that in almost every instance the RO1 review sheets from submitted grants (scored and unscored) continue to characterize the research environment as very supportive of the proposed projects. Of particular note in regard to the past year¿s activity was the development of a University-wide plan to support CRFs. There is a clear consensus on the part of both UM investigators and administrators that the long-term operation of all of the Cores is critical to University's (and COBRE) mission of building competitive programs in biomedical research. It is also readily acknowledged that the critical mass of investigators on campus will not likely grow to such an extent that a majority of these CRFs can be supported solely on the basis of user fees. Thus, continued support will be dependent upon a multifaceted strategy that includes: infrastructure grants (e.g., COBRE, EPSCoR), State match, individual RO1s, multi-investigator grants, and the University¿s Office of the VP for Research. A management plan is also in place. The four CRF directors comprise a steering committee and advisory group with a number of specific goals including: (a) CSFN ¿research roundtable,¿ (b) budget, (c) CSFN reporting functions, and (d) overall facility integration and management. In addition to the four directors, the COBRE PD (R Bridges), the VP for Research, (D Dwyer), Asst to the COBRE PD (K Stewart), and two external advisory members will serve on the steering committee (quarterly meetings) that is responsible for the fiscal, staff, reporting and operations. This committee will eventually grow to include the other Core Facilities on campus.