COBRE: CORE A: ADMIN CORE; EXPANDING U OF ALASKAS HEALTH RESEARCH CAPABILITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项COBRE赠款建立阿拉斯加土著健康研究中心是基于一个以社区为基础的参与性研究范式，促进基础和应用研究。总体目标是促进一个可持续的，NIH资助的研究中心的发展，专门致力于确定与阿拉斯加原住民体重增加，2型糖尿病和心血管疾病相关的文化行为，营养和遗传风险/保护因素。行政核心提供基础设施，以支持偏远农村阿拉斯加原住民社区的研究。第五年行政核心的成就包括：从三个新的村庄获得批准收集数据。所有这些村庄在历史上都与已经抽样的村庄有着重要的关系;因此，许多人与当前的参与者有联系。这将增加我们的样本用于遗传分析的能力。B。确定了五名竞争性续约的潜在研究者，其提案已获得EAC批准，并确定了支持这些项目的核心结构。得到了那些村庄对更新的支持，表明他们愿意参与继续研究。在展示第一轮数据收集的结果后，计划与我们的社区合作伙伴进行续约。C.我们已经获得了大学的持续支持，为更新所需的空间和职位，这将使我们能够建立一个长期的生物医学研究计划。当新的国家研究资金可用时，该大学已将生物医学研究作为其首要资助重点之一。D.基础设施已发展到60多名全职和兼职调查员和支助人员。这一能力使我们能够在这项研究中招募907名Yupik参与者。它已经刺激了一个R 01，一个R24，两个R21，一个R 03和一个R34的提交。CANHR调查人员收到了四笔R系列赠款。E.由于数据分析取得了充分的进展，CANHR调查员的工作效率显著提高。他们在国家和区域会议上发表了60篇摘要，出版了20篇文章或书籍，出版了21篇文章或书籍章节，目前有12篇文章提交审查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This COBRE grant to establish the Center for Alaska Native Health Research is based upon a community-based participatory research paradigm that fosters basic and applied research. The overall goal is to facilitate the development of a sustainable, NIH-funded research center specifically focused on identifying the cultural-behavioral, nutritional, and genetic risk/protective factors associated with increased weight, type two diabetes, and cardiovascular disease among Alaska Natives. The Administrative core provides infrastructure to support this research among remote rural Alaska Native communities. Accomplishments of the Administrative core for year five include: A. Received approval from three new villages to gather data. All of these villages have significant relationships historically to those villages already sampled; therefore, many individuals are related to current participants. This will increase the power of our sample for genetic analyses. B. Identified five prospective investigators for the competitive renewal whose proposals have been approved by the EAC and identified the core structures to support these projects. Received support from the villages for the renewal indicating their willingness to participate in continued research. Planned the renewal with our community partners after presenting results of the first round of data gathering. C. We have secured the continued support of the University for the space and positions needed for the renewal, which will allow us to build a long-term biomedical research program. The university has made biomedical research one of its top funding priorities when new state research dollars become available. D. Infrastructure has grown to over 60 full- and part-time investigators and support staff. This capacity has allowed us to enroll 907 Yup¿ik participants in the study. It has stimulated submissions of one R01, one R24, two R21s, one R03, and one R34. Four R-series grants were received by CANHR investigators. E. Productivity of CANHR investigators has significantly increased since data analysis has progressed adequately. They have presented 60 abstracts at national and regional conferences, have 20 articles or books in press, had 21 articles or book chapters published, and currently have 12 articles submitted for review.