LSU DENTAL COBRE: STATISTICAL CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。导言：统计核心的总体任务是为科布雷的项目在研究设计、样本量估计/统计能力分析、统计方法和数据库管理等领域提供支助。统计核心不仅在提供统计服务方面发挥关键作用，而且在促进初级首席调查员了解研究设计和数据分析的重要性方面也发挥了重要作用。目标：统计核心的活动以下列5个具体目标为指导。(1)就研究设计、样本量估计、统计分析计划和研究建议咨询初级原则调查人员(JPI)。(2)数据库管理系统和质量控制程序的开发和管理。(3)研究数据的统计分析、结果的表述和解释。(4)教育服务，支持研究人员在研究设计和分析方面的发展。(5)加强统计核心服务，为COBRE带来最先进的能力。方法：统计核心积极招募理科硕士水平的生物统计师。每个项目JPI都与统计核心PI进行了一对一的会面，讨论了研究问题。确定了支持科布雷研究工作的基本计算需求。我们与选管会会面，并收到宝贵的意见。结果：统计核心成功招聘了一名统计员。Mercante博士和Simonsen博士分别就统计学和流行病学中的设计和分析问题向JPIS举办了研讨会。已为利·S博士项目开发了数据库。我们协助波特-威廉姆斯博士设计了一项先导性研究。我们与瓦斯塔迪斯博士合作解决了吸烟问题。我们购买并安装了一台新服务器。讨论：统计核心在实现所述目标方面取得了重大进展，并将继续与各JPIS密切合作，为其研究提供指导和支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The overall mission of the Statistical Core is to provide support in the areas of study design, sample size estimation/statistical power analyses, statistical methodology and database management for the projects in the COBRE. The Statistical Core has a crucial role in not only providing statistical services but in contributing to the mentoring process for the junior principal investigators (JPIs) in developing their understanding of the importance of study design and data analysis. Objective: The activities of the Statistical Core are guided by the following 5 specific aims. (1) Consultation with Junior Principle Investigators (JPIs) on study design, sample size estimation, statistical analysis plan, and research proposal. (2) Development and management of database management system and quality control procedures. (3) Statistical analysis of study data, presentation and interpretation of results. (4) Educational services to support investigator development in study design and analysis. (5) Enhancement of statistical core services to bring state of the art capabilities to the COBRE. Methods: The Statistical Core actively recruited for an M.S. level biostatistician. Each project JPI met one on one with the Statistical Core PI to discuss study issues. Essential computing needs to support the research efforts of the COBRE were identified. We met with the EAC and received valuable feedback. Results: The Statistical Core successfully recruited an statistician. Dr.s Mercante and Simonsen presented seminars to the JPIs on design and analysis issues in statistics and epidemiology, respectively. A database has been developed for Dr. Leigh¿s project. We assisted Dr. Porter-Williams in designing a pilot study. We worked with Dr. Vastardis to resolve the issue of smoking. We purchased and installed a new server. Discussion: The Statistical Core has made significant progress towards the stated objectives and will continue to work closely with the JPIs to provide guidance and support for their research.