Support for the Protein Circular Dichroism Data Bank and the Dichroweb Analysis Server

圆二色谱(CD)是研究蛋白质结构、动力学和折叠的一种成熟而有价值的技术，并经常作为一种标准方法在英国的许多生物和化学实验室使用。这是一项为CD光谱学创建一个全面的电子存档和分析资源的建议，可供结构生物学和生物信息学社区使用。它将包括蛋白质圆二色谱数据库(PCDDB)的运行、管理和开发，这是一个存储和搜索生物大分子圆二色谱的数据库。PCDDB将成为结构分子生物学和生物信息学的资源，以及与蛋白质数据库(PDB)并行的光谱数据共享的公共档案，蛋白质数据库是一个长期存在的、有价值的蛋白质晶体和核磁共振数据的参考数据库。该项目还包括DICHROWEB的运行、升级和维护，DICHROWEB是一种广泛使用的用户友好的圆二色性数据分析在线服务器。这两个生物信息学设施将共同为结构生物学和生物信息学社区提供CD光谱学方面的一揽子支持和支持资源。

Circular Dichroism (CD) spectroscopy is an established and valuable technique for examining protein structure, dynamics, and folding, and is regularly used as a standard method in a large number of UK biological and chemical laboratories. This is a proposal to create a comprehensive electronic archiving and analysis resource for CD spectroscopy that can be used by the structural biology and bioinformatics communities. It will include the running, curation and development of the Protein Circular Dichroism Data Bank (PCDDB), a deposition and searchable data bank for circular dichroism spectra of biomacromolecules. The PCDDB will be a resource for structural molecular biology and bioinformatics, and a public archive for data sharing of spectroscopic data to parallel the Protein Data Bank (PDB), a long-existing and valuable reference data bank for protein crystal and NMR data. This project also includes the operation, upgrading and maintenance of DICHROWEB, a widely-used user-friendly online server for the analysis of circular dichroism data. Together these two bioinformatics facilities will provide a comprehensive package of enabling and supportive resources in CD spectroscopy for the Structural Biology and Bioinformatics communities.