VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE

我们研究了神经递质代谢物和葡萄糖代谢 在被监禁的暴力罪犯纵火犯和健康的志愿者中。 我们发现，低脑脊液（CSF），5-羟基吲哚乙酸， 酸（5-HIAA）浓度和口服葡萄糖期间的低血糖 耐受性测试与彼此冲动的暴力行为有关 和放火 阐明反应性的病理生理学 间接量热法进行的低血糖、高血糖胰岛素钳夹研究 已在40多名罪犯和健康志愿者身上进行。的 尚未分析数据，因为初始功效计算表明 需要更大的样本量 样本采集 对酗酒暴力罪犯的分子遗传学家族研究已经 完成 对临床数据进行了精神病学盲态评定 诊断和所有生化和生理数据已输入 并仔细检查错误。 分子遗传 神经遗传学实验室正在进行分析。 十三 数百个DNA样本，代表芬兰人的随机样本， 是从Leena Peltoven博士那里收到的， 位于赫尔辛基的国家公共卫生研究所。 连同我们自己的 由300名志愿者组成的对照样本，这些样本将 用于确定罕见多态性的真实等位基因频率 在芬兰人口中。

We have investigated neurotransmitter metabolites and glucose metabolism in incarcerated violent offenders, arsonists, and healthy volunteers. We have found that low cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) concentrations, and hypoglycemia during oral glucose tolerance tests are associated with each other and impulsive violent acts and fire setting. To elucidate the pathophysiology of the reactive hypoglycemia, englycemic insulin clamp studies with indirect calorimetry have been performed on more than 40 offenders and healthy volunteers. The data have not been analyzed, because initial power calculations indicated that a larger sample size is necessary. Sample collection for the molecular genetic family study on alcoholic violent offenders has been completed. The clinical data have been blind rated for psychiatric diagnoses and all biochemical and physiological data have been entered in the computers and double checked for errors. Molecular genetic analyses in the Laboratory of Neurogenetics are underway. Thirteen hundred DNA samples, which represent a random sample of Finns, and which are without identifiers, were received from Dr. Leena Peltoven in the National Public Health Institute in Helsinki. Together with our own control sample which consists of 300 volunteers, these samples will be used to establish the true allelic frequencies of rare polymorphisms among the Finnish population.