Small Animal PET (microPET)

描述(由申请人提供)：这项提议的长期目标是通过使用小动物正电子发射断层扫描仪(MicroPET Focus 120)的成像技术来促进我们的知识。该仪器具有高分辨率和高灵敏度，因此可以比以前更详细地研究小动物的生化机制。加州大学欧文分校(UCI)的脑成像中心(BIC)、功能肿瘤成像中心(CFOI)、药理学、解剖学和神经生物学、神经生物学和行为学、生物化学、医学、跨学科烟草使用研究中心(TTURC)、放射性药物实验室(UCI)都参与了使用成像方法来研究正常和异常的生理过程。UCI的研究人员在各种条件下的人体研究中使用正电子发射计算机断层扫描有着悠久的传统。UCI各个中心和部门的大量研究人员参与了啮齿动物模型的研究。购买微型PET扫描仪将使众多项目的研究人员能够在分辨率约为1.5毫米或更低的情况下研究活体脑功能。UCI的研究人员将首次能够准确地非侵入性地评估大脑小区域的功能活动。UCI的影像研究是独一无二的，因为基础动物研究中的研究人员与临床研究密切相关，如各种项目所示。在动物模型上进行的研究将极大地提高我们理解和解释人类研究的能力。新的microPET扫描仪将安装在欧文大厅，这里是BIC和CFOI中心的所在地，里面有人类PET扫描仪、MC-17医学回旋加速器、放射性制药实验室、磁共振扫描仪、光学成像实验室和啮齿动物设施。MicroPET扫描仪将在Jogesh Mukherjee博士的指导下，一个来自五个不同部门(放射学、医学、药理学、神经生物学和行为与生物化学)的团队将到位，为microPET的有效操作和最大限度地利用提供必要的行政、科学和技术专业知识。

DESCRIPTION (provided by applicant): The long-term goal of this proposal is to advance our knowledge by employing imaging techniques using a small animal positron emission tomograph (microPET Focus 120). This instrument has high resolution and high sensitivity and will therefore allow the study of biochemical mechanisms with greater detail in small animals than has been possible before. The Brain Imaging Center (BIC), Center for Functional Onco-Imaging (CFOI), Departments of Pharmacology, Anatomy and Neurobiology, Neurobiology and Behavior, Biological Chemistry, Medicine, Transdisciplinary Tobacco Use Research Center (TTURC), Radiopharmaceutical Laboratories all at University of California-Irvine (UCI) have been involved in using imaging methodology to study normal and abnormal physiological processess. Researchers at UCI have a long tradition of using PET in human studies of various conditions. A large number of researchers at the various centers and Departments in UCI are involved in studying rodent models. The acquisition of a microPET scanner will allow researchers in numerous projects to study in vivo brain function with a resolution of about 1.5 mm or less. For the first time, investigators at UCI will be able to accurately assess functional activity in small regions in the brain noninvasively. Imaging research at UCI is unique in terms of the close association of investigators in basic animal research with clinical research as exemplified in the various programs. Studies carried out on the animal models will greatly enhance our ability to understand and interpret human studies. The new microPET scanner will be housed in Irvine Hall, where the BIC and Center for CFOI are located and houses the human PET scanners, the MC-17 medical cyclotron, radiopharmaceutical laboratories, MR scanners, Optical Imaging Lab and rodent animal facility. The microPET scanner will be under the direction of Dr. Jogesh Mukherjee, and a team from five different departments (Radiology, Medicine, Pharmacology, Neurobiology and Behavior and Biological Chemistry) that will provide administrative, scientific, and technical expertise necessary for the effective operation and maximal utilization of the microPET will be in place.