Endocrinology-Reproductive Physiology Training Grant

说明（由申请人提供）：从研究和健康的角度来看，需要更多地了解生殖机制和有关的健康问题，这是控制人口和间接消除贫穷的一个主要因素。相反，生殖方面的研究也可以为不孕症提供解决方案。这些领域，以及成功完成妊娠至无疾病足月，不仅与母婴健康直接相关，而且正常妊娠也是成年后长期健康的重要关键。威斯康星大学麦迪逊分校的内分泌-生殖生理学（ERP）项目是一个长期的跨部门项目，专注于内分泌和生殖生理学。我们的目标是在生殖生理学和健康前沿的跨学科研究中提供博士前和博士后水平的培训，并提供一个来自整个校园的教师和学生可以见面和协同工作的核心。在各种哺乳动物物种/细胞模型中的研究涵盖了排卵、精子运动和受精、着床和胎盘的神经内分泌和内分泌控制，以及子宫胎盘血流的控制/维持和足月及以后的正常发育。此外，还有几个直接研究发育方面以及与妊娠有关的疾病的教员，包括先兆子痫，青春期的时间，更年期，宫内生长迟缓，多囊卵巢综合征的产前规划和生育的社会/压力抑制。最后，我们的许多教师在更广泛的细胞信号传导领域处于领先地位，这与生殖生理学的各个方面高度相关，一般来说，特别是人类生殖。ERP项目现有研究生31人，其中博士研究生26人（国内18人，国际8人）。自1963年以来，该项目已经培养了129名硕士和156名博士，其中许多人在生殖生理学领域取得了杰出的成就。本提案的目的是为六个博士前职位寻求支持，为期五年。培训建议包括来自ERP的18名培训员，ERP也提供集中管理。这笔资金将支持该项目近一半的合格学生。学员将是博士候选人，在完成至少一年的培训后，每人将获得长达两年的支持。目前博士生平均毕业时间为5-6年。招募少数族裔参加ERP项目是在各个层面寻求的，并通过ERP项目/教师与威斯康星大学系统的协调行动来促进。夏季奖学金、旅行基金和/或两年的弱势群体和少数群体奖学金也支持这些招聘工作。

DESCRIPTION (provided by applicant): From a research and health perspective, the need for a greater understanding of reproductive mechanisms and related health issues is a major factor in population control and, indirectly, the eradication of poverty. Conversely studies in reproduction can also provide solutions to infertility. These areas, as well as the successful completion of gestation to term free of disease are not only of immediate relevance to maternal and fetal health but normal gestation is also an important key to long term health far into adulthood, The Endocrinology-Reproductive Physiology (ERP) Program at the University of Wisconsin, Madison, is a longstanding interdepartmental program focused on the endocrinology and physiology of reproduction. Our aim is to provide training at the predoctoral and postdoctoral level in interdisciplinary research at the forefront of reproductive physiology and health, as well as provide a nucleus by which both faculty and students from across campus can meet and synergize. Research in a variety of mammalian species/cell models cover neuroendocrine and endocrine control of ovulation, sperm motility and fertilization, implantation and placentation as well as control/maintenance of uteroplacental blood flow and to normal development to term and beyond. In addition, there are several faculty directly investigating aspects of development as well as pregnancy related diseases, including preeclampsia, timing of puberty, menopause, intrauterine growth retardation, prenatal programming of polycystic ovarian syndrome and social/stress inhibition of fertility. Finally, many of our faculty lead the field in more general areas of cell signaling, which is highly relevant to all aspects of reproductive physiology, ing general, and human reproduction in particular. The ERP program currently has 31graduate students of which 26 are Ph.D. candidates (18 domestic, eight international). To date, since 1963, the program has graduated 129 M.S. and 156 Ph.D. candidates, many of who have gone on to prominent careers in reproductive physiology. The aim of this proposal is to seek support for six predoctoral positions for five years. The training proposal includes 18 trainers from the ERP, which also provides centralized administration. This funding will support almost half of the eligible students in the program. Trainees will be Ph.D. candidates and will be supported for up to two years each after they have completed at least one year of training. The average time to graduation for Ph.D. candidates is currently 5-6 years. The recruitment of minorities to the ERP program is sought at all levels and is facilitated by the coordinated actions of the ERP program/faculty together with the University of Wisconsin system. Summer Studentships, travel funds and/or two year Disadvantaged and Minority Fellowships also support these recruitment efforts.