TRAINING IN ORTHOPEDIC SKELETAL BIOLOGY

描述（由申请人提供）：这是一个综合的博士前和博士后培训支持的应用程序，将把尖端的临床策略与骨骼组织修复和再生的机制和生物学的实验研究结合起来。该提案基于以拉什大学医学中心解剖学和细胞生物学系为中心的骨骼生物学计划，与整形外科系合作（其中包括该国首屈一指的临床整形外科团体之一以及杰出的基础科学家团体）。来自拉什其他两个临床部门的教师（来自内科和整形外科的流变学部门）预计将作为导师或共同导师参加。该计划的目的是为博士生，博士后研究员和对骨骼生物学多学科领域的学术生涯感兴趣的医学生提供教育，培训和研究机会。该计划将强调骨骼修复和再生的机制，以指导培训骨科，风湿病学和颅面外科的基础生物研究基础。我们正在请求支持3名研究生，2名博士后研究员和2名短期研究实习生。除了传统的博士生和MD/博士生，将特别努力招收寻求MD/MS学位的学生。虽然我们的MD/MS计划是相对较新的，谁参加了所有的学生都在一个非常令人鼓舞的轨道上成为医生，科学家。我们认为这条赛道是特别重要的学生感兴趣的外科事业，因为非常长的临床培训要求。因此，强调MD/MS（而不是MD/PhD）仍然允许有意义的密集研究经验，但只增加了一年（而不是三年）的整个培训方案。在博士后阶段，我们计划特别关注MD和MD/PhD的招聘。短期研究实习生机制将被用作向仍在考虑MD/MS或MD/PhD选项的医学生介绍研究的一种方式。我们正在采取这一战略，以帮助支持骨科骨骼生物学的医生科学家的数量。相关性：这笔赠款将帮助培训科学家，以改善受损骨骼和关节的愈合。目前的骨科手术是成功的，但我们希望通过更好地了解身体用于自我修复的潜在病理和机制来改善结果。最终，治疗将更多地依赖于身体自我更新的自然能力，而不是使用人工材料。

DESCRIPTION (provided by applicant): This is an application for integrated pre- and post-doctoral training support that will bring together cutting edge clinical strategies with experimental investigations on the mechanisms and biology of skeletal tissue repair and regeneration. The proposal is based in the skeletal biology program centered in the Department of Anatomy & Cell Biology at Rush University Medical Center in partnership with the Department of Orthopedic Surgery (which includes one of the premier clinical orthopedic groups in the country as well as an outstanding group of basic scientists). Faculty from two other clinical departments at Rush (Section of Rheumatology from the Department of Internal Medicine and the Department of Plastics & Reconstructive Surgery) are expected to participate as mentors or co-mentors. The objective of the proposed program is to provide education, training and research opportunities to doctoral students, postdoctoral fellows and medical students interested in academic careers in the multi-disciplinary area of skeletal biology. The program will emphasize mechanisms of skeletal repair and regeneration in order to direct training to basic biological research foundations for orthopedics, rheumatology and craniofacial surgery. We are requesting support for 3 graduate students, 2 post-doctoral fellows and 2 short-term research trainees. In addition to traditional PhD students and MD/PhD students, a special effort will be made to recruit students seeking combined MD/MS degrees. Although our MD/MS program is relatively new, all of the students who have participated are on a very encouraging track of becoming physician-scientists. We think this track is particularly important for students interested in surgical careers because of the extremely long clinical training requirements. Thus, emphasis on the MD/MS (as opposed to the MD/PhD) still permits a meaningful intense research experience, but adds only one year (as opposed to three years) to the entire training regimen. At the post-doctoral level, we plan to pay special attention to the recruitment of MDs and MD/PhDs. The short-term research trainee mechanism will be used as a way to provide an introduction to research for medical students who are still considering the MD/MS or MD/PhD option. We are taking this strategy to help bolster the number of physician-scientists in orthopedic skeletal biology. Relevance: This grant will help train scientists to improve healing of damaged bone and joints. Current orthopedic procedures are successful, but we hope to improve outcomes through a better understanding of the underlying pathologies and mechanisms the body uses to repair itself. Eventually, treatments will rely more on the body's natural ability at self-renewal and less on the use of artificial materials.