AACR-TREC-NIH Think Tank Conference: Energy Balance and Cancer; Mechanisms and Me

描述(申请人提供)：肥胖症已经达到了全球流行的程度，现在被认为是公共卫生的一个主要危机。癌症是与肥胖相关的许多并存疾病之一，可能在病因上也与肥胖有关，特别是肥胖与结肠癌、绝经后乳腺癌、食管腺癌、子宫癌、肾癌等之间存在着特别强的流行病学联系。这项提案寻求资金支持AACR-TREC-NCI主办的智库会议，题为能量平衡与癌症；机制和调解人，将于2008年2月24日、25日和26日在弗吉尼亚州兰斯敦的兰斯敦度假村会议中心举行。 虽然有强有力的流行病学证据将肥胖与癌症联系起来，但这种关系的机制和中介以及它们之间的潜在相互作用还没有明确的定义，因此限制了调节它们在癌症预防、进展和治疗中的作用的尝试。这次会议将研究肥胖作为能量平衡失调的一种表现，以及由此产生的将这些紊乱与癌症联系起来的媒介和机制。重点讨论的主题包括肥胖、运动和限制卡路里与癌症的关系，以及(1)胰岛素、生长因子和胰岛素对癌症的抵抗力；(2)前列腺素和二十烷类化合物与癌症；(3)炎症和压力因素与癌症；(4)脂肪因子和脂肪组织产品与癌症的机制和媒介；(5)肥胖与癌症的激素媒介。会议的总体目标是(1)促进这些领域和相关领域的专家进行具有挑衅性的智囊团讨论，(2)更好地确定将肥胖和癌症联系起来的潜在媒介，(3)定义它们的作用机制和相互作用，(4)概述研究议程，以指导对这些关系的关键调查，以及(5)确定最有希望的候选人，作为实验室、临床和转化研究的标记和潜在目标。

DESCRIPTION (provided by applicant): Obesity has reached global pandemic proportions and is now considered a major crisis in public health. Cancer is among the many comorbid conditions associated with, and probably etiologically related to obesity, with a particularly strong epidemiological relation identified between obesity and colon cancer, post menopausal breast cancer, esophageal adenocarcinoma, uterine cancer, renal cell cancer and others. This proposal seeks funding to support an AACR-TREC-NCI Sponsored Think Tank Conference entitled Energy Balance and Cancer; Mechanisms and Mediators to be held February 24, 25 and 26, 2008 at the Lansdowne Resort Conference Center, Lansdowne, Virginia. While there is strong epidemiologic evidence connecting obesity to cancer, the mechanisms and mediators of this relation as well as their potential interactions are not clearly defined thus limiting attempts to modulate their effects in cancer prevention, progression and therapy. This meeting will examine obesity as a manifestation of disordered energy balance and the resultant mediators and mechanisms connecting these disorders to cancer. High priority themes for discussion include the relation of Obesity, Exercise and Caloric Restriction to Cancer and Mechanisms and Mediators connecting (1) Insulin, Growth Factors and Insulin Resistance to Cancer; (2) Prostaglandins and Eicosanoids to Cancer; (3) Inflammatory and Stress Factors to Cancer; (4) Adipokines and Fat Tissue Products to Cancer and (5) Hormonal Mediators of Adiposity to Cancer. The overall goals of the meeting are (1) to stimulate a provocative think tank deliberation among experts in these and related fields, (2) to better identify potential mediators connecting obesity and cancer, (3) to define their mechanisms of actions and interactions, (4) to outline a research agenda to guide critical investigations of these relations and (5) to identify the most promising candidates to serve as markers and potential targets for both laboratory, clinical and translational research.