Structure Analysis of Supramolecular Assemblies by Hybrid Method

描述（由申请人提供）：该项目的目标是召开为期四天的研讨会，讨论“混合方法对超分子组装的结构分析”的前沿主题，汇集结构生物学不同分支的专家，主要来自x射线晶体学，电子低温显微镜和计算生物学领域。会议议程还将扩展到生物物理方法、蛋白质组学和细胞生物学。这是继2006年3月、2004年3月和1998年4月就同一主题成功举行的三次研讨会之后的又一次研讨会。它的目标是通过说明混合方法解决具有挑战性的大型系统的力量，并通过确定目前实践的混合方法的局限性和差距，来调查这个令人兴奋的研究领域的艺术状态。研讨会基于以下新兴概念：(1)大分子组件和机器代表了大多数基本过程的结构层次中的关键水平；(2)这些实体可以通过适当的实验方法组合进行最有效的研究，即：“混合方法。”研讨会将于2008年3月12日至16日在加利福尼亚州太浩湖举行的格兰利巴肯会议上举行。其计划包括两个主题演讲，七个平台会议（邀请演讲（70%）和从提交的摘要中选择的演讲（30%）），以及两个海报会议。会议主题如下：大分子细丝的杂交方法；膜配合物的杂化方法研究动态装配的混合方法，混合分析的计算方法混合方法；大分子机器；细胞组织和细胞蛋白质组学的混合方法。Drs。D. Hanein和W. Sundquist担任会议主席。A. Steven， B. Geiger， C.M. waterman - stover， R.M. Stroud， W. Baumeister是组委会成员。该研讨会将广泛宣传，并将尽组织者所能实现的包容性和多样性敏感，并将允许150名参与者的限制。

DESCRIPTION (provided by applicant): The goal of this project is to convene a four-day Workshop on the cutting-edge topic of "Structural Analysis of Supramolecular Assemblies by Hybrid Methods," bringing together specialists in diverse branches of structural biology, drawing primarily from the fields of x-ray crystallography, electron cryomicroscopy, and computational biology. The agenda will also extend to biophysical methods, proteomics and cell biology. This Workshop follows three successful meetings on the same theme in March 2006, March 2004 and April 1998. Its goal is to survey the state of the art in this exciting area of research by illustrating the power of hybrid methods to tack-le challenging mega systems and by identifying limitations and gaps in hybrid methods as currently practiced. The Workshop is based on the emerging concepts that (1) macromolecular assemblies and machines represent the pivotal level in the structural hierarchy for most fundamental processes; and (2) these entities may be most effectively studied by appropriate combinations of experimental methods, i.e. "hybrid approaches." The Workshop will be held from March 12-16, 2008 at the Granlibakken Conference in Lake Tahoe, CA. Its program will consist of two keynote lectures, seven platform sessions with both invited talks (70%) and talks selected from submitted abstracts (30%), and two poster sessions. The platform session topics are as follows: Hybrid Approaches to Macromolecular Filaments; Hybrid Approaches to Membrane Complexes; Hybrid Approaches to Dynamic Assemblies, Computational Approaches to Hybrid Analysis; Hybrid Approaches Macromolecular Machines; Hybrid Approaches to Cellular Organization, and Cellular Proteomics. Drs. D. Hanein and W. Sundquist serve as Chairs of the meeting and Drs. A. Steven, B. Geiger, C.M. Waterman-Storer, R.M. Stroud, W. Baumeister are members of the organizing committee. The Workshop will be extensively advertised and will be as inclusive and diversity-sensitive as the organizers can achieve and the 150-participant limit will allow.