HU/JHU Head and Neck Cancer Translational Research and *

描述(由申请人提供)： 头颈癌是全球第六大常见癌症，在美国排名第七。非洲裔美国人男性头颈部癌症的发病率大约是非非洲裔美国人男性的两倍，5年相对存活率较低(36.2%比47.6%)。霍华德大学医疗机构是一家为少数族裔服务的教育机构和医疗中心，是华盛顿特区/巴尔的摩大都市区重要的教育和临床资源，服务于大量低收入非裔美国患者。然而，霍华德大学对翻译研究工作的招聘和支持面临着巨大的挑战。这项提议的目标是通过霍华德大学医疗机构和约翰霍普金斯大学医疗机构的头颈部癌症中心之间的高度合作努力，创造一个合作环境，加强霍华德大学医疗机构与头颈癌相关的转化性研究和教育。这项合作的重点是转化性研究和研究培训，以及教育努力，重点是加强头颈部癌症的转化性研究和对霍华德医疗机构社区的影响。具体目标将是：1)支持霍华德大学医疗机构与约翰·霍普金斯大学头颈部癌症中心和西德尼·基梅尔癌症中心之间的合作癌症研究项目；2)提供合作培训和指导计划，促进霍华德医学和牙科学生和教职员工在癌症研究方面的研究；3)建立教育计划，在少数族裔服务机构的背景下，提高转化癌症研究的知识，使其适用于头颈部癌症的病因、预防、诊断和治疗。将以协同的方式促进和协调这些目标，从而加强在霍华德大学癌症中心内建立合作翻译研究的文化，以及与约翰·霍普金斯医疗机构的研究人员建立有效的长期伙伴关系。这些目标将通过霍华德医疗机构的个人指导指导来实现，以通过国家癌症研究所的传统机制发展成为独立的调查人员。

DESCRIPTION (provided by applicant): Head and neck cancer is the sixth most common cancer worldwide, the seventh most common solid tumor in the United States. The incidence of head and neck cancer in African American men has been approximately two times higher than that of non African American men with a lower 5-year relative survival (36.2% vs. 47.6%). Howard University Medical Institutions is a minority-serving educational institution and medical center that is an important educational and clinical resource in the Washington DC/ Baltimore metropolitan area and serves a large community of low-income African American patients. However, recruitment and support for translational research efforts at Howard University has significant challenges. The goal of this proposal is to create a collaborative environment to enhance translational research and education related to head and neck cancer at the Howard University Medical Institutions through a highly collaborative effort between the Howard University Medical Institutions and the Head and Neck Cancer Center at the Johns Hopkins Medical Institutions. This collaboration is focused on translational research and research training as well as educational efforts focused on enhancing head and neck cancer translational research and impact on the Howard Medical Institutions community. Specific aims will be: 1) to support collaborative cancer research projects between the Howard University Medical Institutions and the Head and Neck Cancer Center and Sidney Kimmel Cancer Center at Johns Hopkins 2) to provide collaborative training and mentoring program for promoting Howard medical and dental students and faculty in cancer research, 3) to establish education programs that advance the knowledge of translational cancer research as it applies to etiology, prevention, diagnosis, and treatment of head and neck cancer in the context of minority-serving institutions. These aims will be promoted and coordinated in a synergistic manner, such that they reinforce the creation of a culture of collaborative translational research within the Howard University Cancer Center as well as an effective long-term partnership with investigators at the Johns Hopkins Medical Institutions. These goals will be pursued by directed mentorship of individuals at Howard Medical Institutions to develop as independent investigators via traditional mechanisms of the National Cancer Institute.