NALTREXONE HCL TO DECREASE INCIDENCE & SEVERITY OF SELF-INJURY IN MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对实验灵长类动物的自伤行为(SIB)的药理学干预措施很少被彻底评估。作为正在进行的纳曲酮HC(以10 mg/ml的浓度混合成可口的糖浆)长期评估的一部分，到目前为止，已经记录了12只笼子里的亚成年和成年雄性恒河猴的行为数据和伤害发生率。此外，伤害的发生率和严重程度被用作评估对另外五名很少或从不表现出自咬行为的男性受试者进行干预的唯一因变量。在开始治疗前和整个研究期间定期进行体格检查、全血计数、血液化学、尿液分析和行为观察，总计153小时。动物按3.2 mg/kg剂量灌胃，每24小时一次。对个体进行重新评估，每隔两到四周逐渐增加给药间隔，最长间隔为96小时。在治疗的第一周内，观察到几个受试者自咬的频率显著减少。在行为研究的所有受试者中，每天服药和每隔一天服药的自咬率都明显较低。比赛的频率较低，比赛的长度不受影响。纳曲酮没有改变其他行为的水平，表明该药物没有全身或镇静作用。在所有研究对象中，自伤的发生率明显较低。结果表明养育背景可能有影响；在社会环境中，母亲养育的动物的进步最显著。环境因素，而不是内源性因素，可能在苗圃饲养的猕猴和被剥夺了社会地位的猕猴中更为普遍。继续的研究将评估这种可能性，以及其他剂量水平和长期疗效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Few pharmacological interventions for self-injurious behavior (SIB) in laboratory primates have been thoroughly evaluated. As part of an ongoing long-term evaluation of naltrexone HC (compounded into a palatable syrup at 10mg/ml), behavioral data and incidence of wounding has been recorded for 12 caged subadult and adult male rhesus macaques to date. In addition, the incidence and severity of wounding is being used as sole dependent variables for assessing this intervention in an additional five male subjects that rarely or never display self-biting behavior. Physical exams, complete blood counts, blood chemistry, urinalysis, and behavioral observation totaling 153 h were performed before beginning treatment and at regular intervals throughout the duration of the study. Animals were dosed at 3.2mg/kg orally once every 24 hours. Individuals were reassessed and dosing intervals were gradually increased every two to four weeks, with a maximum interval of 96 hours. Dramatic reductions in the frequency of self-biting were observed within the first week of treatment for several subjects. Over all subjects studied behaviorally, rates of self-biting were significantly lower with both the daily and every-other-day dosing. Bouts were less frequent, and bout length was unaffected. Naltrexone did not alter levels of other behaviors, indicating no generalized or sedating effect of the medication. Incidence of self-wounding was markedly lower among all subjects studied. Results suggest a possible influence of rearing background; the most dramatic improvements were seen in animals mother-reared in a social setting. Environmental as opposed to endogenous triggers may be more prevalent in nursery-reared and socially-deprived macaques. Continued research will evaluate this possibility, as well as other dosing levels and long-term efficacy.