PROJECT 1

项目1-蜂窝网络。 项目负责人：J.布罗奇(莫尔比奥) 该中心的六个研究小组致力于细胞内网络的不同例子。在所有情况下， 对信号网络进行建模的方法由实验生物学家和 注重数学的理论家。实验者和科学家之间的动态相互作用 理论家每天都在发生，这是因为物理上的接近和 与中心相关的每个人的协作思维模式(参见图1)。此外，所有小组都在很大程度上利用了该中心的核心设施；微阵列、质谱学和成像设施为实验者提供了获取必要的定量数据和 计算核心提供了存储和分析这些数据的方法。正在解决细胞生物学中的两个基本问题：转录网络(即定义和分析细胞如何协调其在变化的环境下发生的复杂转录变化)和细胞生长的协调(即细胞如何在广泛的生长速度和环境扰动下保持平衡生长)。

PROJECT 1 - INTRACELLULAR NETWORKS. Project Leader: J. Broach (Molbio) Six research groups in the Center work on distinct examples of intracellular networks. In all cases the approach to modeling a signaling network consists of a joint effort of experimental biologists and mathematically oriented theorists. The dynamic interplay between the experimentalists and the theorists occurs on a daily basis and is made possible by the close physical proximity and the collaborative mind set (see Figure 1) of everyone associated with the Center. In addition, all the groups draw heavily on the core facilities of the Center; microarray, mass spectrometry and imaging facilities provide the experimentalists with the means of acquiring requisite quantitative data and the computational core provides a means of storing and analyzing those data. Two fundamental problems in cellular biology are being addressed: transcriptional networks (i.e. defining and analyzing how cells coordinate their complex transcriptional changes that occur under changing environments, and coordination of cell growth (i.e. how cells manage to maintain balanced growth over a wide range of growth rates and environmental perturbations).