DOSE SPARING PROPRIATARY DRUG IN BABOONS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项狒狒研究将检测免疫刺激性DNA序列与重组核蛋白偶联的能力，以增强标准三价流感疫苗（TIV）的免疫原性，并可能允许剂量节省。 本研究将包括6组动物，每组5只动物，以检测各种给药模式。 疫苗制剂将通过四头肌内注射给药。 该实验将有助于确定测试剂量是否可以增强对减少剂量的TIV的体液免疫应答。 这项研究可能对社会有益，因为它将有助于开发新的和改进的流感疫苗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study in baboons will test the ability of immunostimulatory DNA sequences conjugated to recombinant nuclear protein to enhance the immunogenicity of the standard trivalent influenza vaccine (TIV) and possibly allow dose-sparing. The study will consist of 6 groups of 5 animals per group to test various dosing patterns. The vaccine formulations will be administered by intramuscular injection in the quadriceps. This experiment will help determine if the tested doses can enhance the humoral immune response to reduced doses of TIV. This study may be beneficial to society since it will help in the development of a new and improved influenza vaccine.