VAGINAL ABSORPTION OF GNRH II ANALOG-GEL IN THE BABOON

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们以前已经证明了GnRH II类似物作为避孕剂在恒河猴和食蟹猴皮下注射时的有效性。我们的研究还表明，这种类似物直接作用于宫腔内，影响其避孕活性，而不依赖于脑垂体。在这些研究中，我们将确定这种药物和其他类似的类似物是否可以通过灵长类动物的阴道释放并到达外周循环。预计获得的数据将支持我们的假设，并为我们提供基本的灵长类数据，使我们能够开发使用阴道分娩途径进行临床测试的方案

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously demonstrated the effectiveness of a GnRH II analog as a contraceptive agent when administered subcutaneously to the rhesus and cynomologus monkeys. Our studies have also shown that this analog acts directly in the intra-uterine tract to effect its contraceptive activity, independent of the pituitary. In these studies we will determine if this agent and other similar analogs can be delivered vaginally in primates and reach the peripheral circulation. It is anticipated that the data obtained will support our hypothesis and provide us with basic primate data that will enable us to develop protocols for clinical testing using a vaginal route of delivery