MRI EVALUATION OF A GUINEA PIG MODEL OF ARTHRITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 常规的T1和T2成像技术对于观察晚期结构形态是有用的 股骨-胫骨关节内软骨的变化，但对早期生化反应不敏感 改变。T1P加权成像作为早期骨性关节炎的一种诊断手段显示出了良好的前景。 T_1p驰豫时间常数对体水分子与水的相互作用很敏感 细胞外基质大分子，如关节软骨中的蛋白多糖。在这项研究中， 我们评估了T1p磁共振成像在动物模型中表征骨关节炎变化的有效性。 (Dunkin-Hartley豚鼠)自发性骨关节炎形成。未来的研究可能会允许 T1p MRI用于评价骨关节炎潜在治疗方法的疗效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Conventional T1 and T2 imaging techniques are useful for observing late structural morphological changes to the cartilage within the femoral-tibial joint but are insensitive to early biochemical changes. T1p weighted imaging has shown promise as a diagnostic measure of early osteoarthritis. T1p relaxation time constant is sensitivity to the interaction between bulk water molecules and extracellular matrix macromolecules such as the proteoglycans in articular cartilage. In this study, we evaluate the efficacy of T1p MRI to characterize osteoarthritis changes in an animal model (Dunkin-Hartley guinea pig) of spontaneous osteoarthritis formation. Future studies may allow T1p MRI to evaluate efficacy of potential therapies for OA.