NORTHEAST STRUCTURAL GENOMICS CONSORTIUM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 美国国家普通医学科学研究所(NIGMS)支持大型东北结构基因组联盟(NESGC)确定独特的蛋白质结构。蛋白质结构倡议(PSI-2)的综合第二阶段必须产生大量独特的蛋白质结构，以满足PSI-2关于测序基因结构复盖的目标。NESGC还必须开发技术和方法，使蛋白质的生产和结构确定成本更低、效率更高、更有可能成功。这些结构将帮助研究人员发现蛋白质的功能，设计更好的实验，并研究关键的生物医学问题，如蛋白质折叠、结构预测以及蛋白质家族和折叠的组织。此外，这些研究的结果将有助于更快地确定有前景的新的基于结构的药物，更好地治疗遗传和传染病。 在此基础上成功确定了ET72的晶体结构，并已存入蛋白质数据库(代码1YW6)。ET72是一种产自大肠杆菌的琥珀酸谷氨酸脱琥珀酸酶。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Institute of General Medical Sciences (NIGMS) supports large-scale Northeast Structural Genomics Consortium (NESGC) for the determination of unique protein structures. The integrated second phase of the Protein Structure Initiative (PSI-2) must produce a large number of unique protein structures to meet the PSI-2 goals for structural coverage of sequenced genes. NESGC must also develop technologies and methodologies that will make the production and structural determination of proteins less expensive, more efficient, and more likely to be successful. These structures will help researchers discover the functions of proteins, design better experiments, and study key biomedical problems such as protein folding, structure prediction, and the organization of protein families and fold. In addition, the results of these studies will be useful for faster identification of promising new structure-based medicines, better therapeutics for treating both genetic and infectious diseases. The crystal structure of ET72 has been successfully determined based on the data, and has been deposited in the Protein Data Bank (code 1YW6). ET72 is a succinylglutamate desuccinylase from E. coli.