Microarray Technology for Proteomics Research

描述(由申请人提供)：需要新的技术来分析基因组的蛋白质编码内容。我们建议开发一种新的技术，用于低成本地制造和分析高度多元化的多肽微阵列。我们将开发用于大规模蛋白质结合研究的阵列制作和使用方法。 与公共健康相关：我们正在开发的蛋白质阵列技术将有助于实现对蛋白质的大规模研究。这对于确定新的药物靶点和药物开发是有用的。它还有助于分析自身免疫性疾病或癌症中的蛋白质异常，因此可能导致疾病诊断和治疗的医学进步。

DESCRIPTION (provided by applicant): There is a need for new technologies to enable the analysis of the protein coding content of a genome. We propose to develop a novel technology for fabrication and analysis of highly multiplexed peptide microarrays at low cost. We will develop methods for array fabrication and utilization for large scale protein binding studies. PUBLIC HEALTH RELEVANCE: The protein array technology we are developing will help to enable large-scale studies of proteins. This is useful for identifying new drug targets and for drug development. It is also useful for analysis of protein abnormalities in autoimmune disease or cancer, and therefore may result in medical advances in the diagnosis and treatment of disease.