Translational Research in Neurobiolgy of Disease Training Program

描述（由申请人提供）： 这个建议是为明尼苏达大学的“疾病神经生物学转化研究”提供培训补助金。这个项目的培训对象是正在攻读博士学位的研究生。通过神经科学研究生课程获得学位，2）博士后研究员，3）临床研究员。我们面临的挑战是培养基础神经科学家，他们将对临床相关的问题有一个评价，并培养临床医生，他们对基础科学工具的基本原理有一个评价，这样他们就可以共同努力，加快转化神经科学的步伐。拟议的培训计划在神经科学研究生课程的第二年为博士前学生提供资金，因为他们已经致力于翻译神经科学轨道。博士后研究员和临床研究员可以在培训的任何时候获得资助，但必须致力于转化神经科学的培训。该培训计划是围绕教学课程工作的核心，其中包括疾病的神经生物学课程，和神经科学实验室暑期课程为所有学员。这些课程的目的是产生基础和临床神经科学家之间的对话和互动，以促进转化研究。一组超过37名培训师建议，反映了基础和临床神经科学的研究技术的多样性，但与神经变性和修复的主题重点。研究兴趣范围从神经退行性疾病的分子机制到涉及干细胞和重组DNA的疗法。每位培训师都指导一个富有成效的研究项目，并表现出对教学和培训的承诺。代表整个大学的11个部门，培训师通过参与神经科学和转化神经科学研究的研究生课程而团结起来。学员将在基础和临床神经科学方面获得强大，广泛的基础，以建立他们的转化研究事业。

DESCRIPTION (provided by applicant): This proposal is for a training grant, "Translational Research in Neurobiology of Disease", at the University of Minnesota. Trainees of this program are 1) graduate students who are pursuing a Ph.D. degree through the Graduate Program in Neuroscience, 2) postdoctoral fellows, and 3) clinical fellows. The challenge is to train basic neuroscientists who will have an appreciation for clinically relevant problems, and to train clinicians who have an appreciation of the fundamental principals of tools of basic science so that they can work together and accelerate the pace of translational neuroscience. The proposed training program funds predoctoral students during their second year in the Graduate Program in Neuroscience after they have committed to the translational neuroscience track. Postdoctoral fellows and clinical fellows can be funded at any point in their training, but must be committed to training in translational neuroscience. The training program is built around a core of didactic course work that includes a course in Neurobiology of Disease, and a Neuroscience Laboratory summer course for all trainees. These courses are designed to produce a dialog and interactions among basic and clinical neuroscientists to facilitate translational research. A group of over 37 trainers are proposed that reflects the diversity of research techniques in basic and clinical neuroscience, but with a thematic focus on neural degeneration and repair. Research interests range from molecular mechanisms underlying neurodegenerative disorders to therapies involving stem cells and recombinant DNA. Each trainer directs a productive research program and has demonstrated commitment to teaching and training. Representing 11 departments throughout the university, the trainers are united by their participation in the Graduate Program in Neuroscience and translational neuroscience research. The trainees will be provided with a strong, broad foundation in basic and clinical neurosciences upon which to build their translational research careers.