Research Training in Gastroenterology

描述（由申请人提供）： 这是一个竞争性的延续申请，用于更新1999年首次资助的胃肠病学培训计划。自那时以来，20名受训人员得到了支助，其中除4人外，其他人都担任全职学术职务，或在工业界从事全职研究，或仍在接受培训。该计划的目标是为致力于研究胃肠病学或相关领域的年轻研究人员提供两三年的研究培训。研究培训的类型包括基础，转化或临床研究，或这些的组合。受训者可能是医学博士、医学博士-博士或博士，他们已经完成了临床或研究生培训，正在寻求进一步的胃肠病学研究培训。培训将主要包括指导研究，将提供密集的实践经验。还将提供一系列教学课程、讲习班、研讨会和会议。在以病人为导向的研究受训者将有望完成课程的工作和论文要求，以获得MMS，MPH或同等学位。所有学员将被要求在研究培训的第三年提交K系列NIH奖或研究基金会支持的赠款申请。学员将由经验丰富的研究导师监督，他们具有广泛的兴趣和专业知识，从基础细胞和分子生物学到临床研究。一个由凯利博士、罗布森博士、特霍斯特博士和哀叹博士以及一两名其他培训教员组成的培训委员会将监测整个研究培训计划，选择合适的候选人并监测进展情况。实习生研究计划将在四个广泛的领域提供，这些领域与该部门的卓越临床中心相结合：1。肠道感染和免疫2.）肝损伤和纤维化3.）血管生物学和4.）上皮生物学。该培训计划将利用GI部门、内科和外科以及哈佛医学院和公共卫生学院的优秀GI研究基地。培训计划还将受益于BIDMC组织良好、资金充足的综合临床研究中心，以及两个消化疾病中心的临近，一个在哈佛医学院，另一个在马萨诸塞州总医院。地理信息司在招聘女性和少数民族学员和教员方面有着良好的记录，并为未来的少数民族外联和招聘制定了积极的计划。 公共卫生相关性：该计划将解决一般医学和特别是胃肠病学的一个关键问题：训练有素的医生科学家和基础研究人员的供应减少，重点是GI和肝脏疾病。该计划将把实验室研究与临床问题和问题相结合，以更好地解决我们专业诊断和治疗中的信息差距。我们的最终目标是培养能够成功竞争启动研究资金和入门级教师职位的个人，并继续表现出对基础或临床研究的实质性承诺。

DESCRIPTION (provided by applicant): This is a competing continuation application for renewal of a training program in gastroenterology that was first funded in 1999. Since then, 20 trainees have been supported, of whom all but four are in full time academic positions, or full-time research in industry, or still in training. The goal of this program is to provide two or three years of research training for young researchers committed to a career in investigative gastroenterology or allied fields. The types of research training include basic, translational or clinical research, or combinations of these. Trainees may be MDs, MD-PhDs or PhDs who have finished clinical or graduate training and are seeking further research training in gastroenterology. Training will consist primarily of mentored research that will provide intense hands-on experience. An extensive menu of didactic courses, workshops, seminars and conferences will also be provided. Trainees in patient-oriented research will be expected to complete course work and thesis requirements to obtain an MMS, MPH or equivalent degree. All trainees will be expected to submit grant applications for K-series NIH awards or support from research foundations during the 3rd year of research training. Trainees will be supervised by experienced research mentors with a wide range of interests and expertise from basic cellular and molecular biology to clinical research. A training committee composed of Drs. Kelly, Robson, Terhorst and Lament and one or two other training faculty will monitor the overall research training program, select suitable candidates and monitor progress. Trainee research programs will be available in four broad areas that are integrated with clinical centers of excellence in the Division: 1.) Intestinal Infection and Immunity 2.) Liver Injury and Fibrosis 3.) Vascular Biology and 4.) Epithelial Biology. The training program will take advantage of the outstanding Gl research base within the Gl Division, the Departments of Medicine and Surgery and at Harvard Medical School and School of Public Health. The training program will also benefit from the availability of a well organized and funded General Clinical Research Center at BIDMC, as well as the close proximity of two Digestive Disease Centers, one at Harvard Medical School and a second at Massachusetts General Hospital. The Gl Division has a good track record of recruitment of female and minority trainees and faculty, and has an active plan for future minority outreach and recruitment. PUBLIC HEALTH RELEVANCE: This program will address a critical issue in medicine in general and gastroenterology in particular: the dwindling supply of well-trained physician-scientists and basic researchers focused on Gl and liver diseases. The program will integrate bench research with clinical questions and problems to better address the information gaps in diagnosis and treatment in our specialty. Our ultimate goal is to produce individuals who are able to compete successfully for start-up research funding and for entry level faculty positions and who continue to exhibit a substantial commitment to basic or clinical research.