DEVELOPMENT OF MEDIAL TEMPORAL LOBE FUNCTIONS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目旨在研究（a）猴子海马和周边皮层功能的发展，（B）这些脑区早期损伤对记忆过程和社会联系成熟的长期影响，以及（c）与成年损伤相比，这些早期损伤导致的其他脑系统的解剖学重组。 在本年度，我们继续进行行为训练的猴子，我们已经准备好了海马体的新生儿病变和他们的假手术对照，因为他们正在进入青春期和成年早期。 我们评估了他们在长时间延迟中识别物体和地点的能力，在执行任务时保持在线信息的能力，以及他们的社交技能和情绪反应。 我们开始对另一组6只新生儿外周皮质病变的幼猴以及2只假手术和2只正常幼猴进行行为训练，这些幼猴将作为对照。 这些动物在第二年接受了物体识别记忆，社会互动和情绪反应的测试。 我们将继续对这些动物进行行为测试，因为它们将成熟。 通过这项研究，我们预计大脑对损伤的反应原则可以建立起来，最终将导致发现减轻甚至消除这种影响的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is designed to investigate (a) the development of hippocampal and peripheral cortex functions in monkeys, (b) the long-term consequences of early insult to these brain areas on the maturation of memory processes and social bonds, and (c) the anatomical reorganization of other brain systems resulting from these early lesions as compared to adult lesions. In the current year, we continued to behaviorally trained monkeys that we have prepared with neonatal lesions of the hippocampus and their sham-operated controls as they are reaching adolescence and early adulthood. We have assessed their abilities to recognize objects and places over long delays, to hold information on line while performing a task, as well as their social skills and emotional reactivity. We began to behaviorally train another cohort of 6 infant monkeys with neonatal lesions of the peripheral cortex as well as 2 sham-operated and 2 normal infants that will serve as controls. These animals are being tested on object recognition memory, social interactions and emotional reactivity during their second year. We will pursue the behavioral testing of these animals as they will mature. Through this research we anticipate that principles of the brain's response to damage can be established that will lead ultimately to the discovery of ways in which such effects can be alleviated or even eliminated.