EXERCISE AND OXIDATIVE STRESS MECHANISMS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在最近由NICHD和NIDDK主办的一次会议上，一组全国知名的研究人员敲响了警钟，称新出现的代谢综合征[由肥胖、血脂异常、高血压和高血糖组成的一系列病理因素](1)在儿童和青少年中出现的频率越来越高(2)。如果不加以控制，随着这一代人成年，我们将目睹前所未有的心血管和代谢性疾病，发病率和成本将令人震惊。虽然儿童代谢综合征及其因素的致病机制尚不完全清楚，但最近的研究支持了活性氧物种(ROS)的产生和抗氧化防御之间的失衡所起的作用，从而诱导氧化应激(3-5)。这是令人信服的，因为身体活动和营养是人类体内ROS产生和抗氧化防御机制的最重要的自然发生的修饰物(6-12)。在儿童中，运动、饮食和氧化应激之间的相互作用在代谢综合征发病机制中的关键机制尚未被研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a recent conference sponsored by the NICHD and NIDDK, an alarm was sounded by a group of nationally known investigators that elements of the emerging metabolic syndrome [a constellation of pathologies consisting of obesity, dyslipidemia, hypertension and hyperglycemia] (1) are appearing in increasing frequency in children and adolescents (2). If unchecked, we will witness an unprecedented level of cardiovascular and metabolic disease as this generation becomes adults, and the morbidity and cost will be staggering. While the pathogenic mechanisms of the metabolic syndrome and its elements in children are not fully understood, recent research supports a role for an imbalance between production of reactive oxygen species (ROS) and antioxidant defenses, inducing oxidative stress (3-5). This is compelling because physical activity and nutrition are among the most important naturally occurring modifiers of ROS production and antioxidant defense mechanisms in humans (6-12). In children, key mechanisms governing the interactions among exercise, diet, and the regulation of oxidative stress in the pathogenesis of the metabolic syndrome have yet to be investigated.