DETECTION OF INTER-VERTEBRAL DISC DEGENERATION USING T1? MRI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 退行性间盘疾病(DDD)是以下人群中背部相关残疾的最常见原因 北美成年人。DDD转化为与健康相关的近1000亿美元 仅在美国的支出。在被诊断为DDD的人中，数千人 个人接受矫正的脊柱手术，如全椎间盘置换和腰椎融合术。 即使在这些手术盛行的情况下，手术的总体长期效果在 关于整体脊柱健康的问题尚不清楚。虽然手术可能会治疗特定的位置，即 被认为引起疼痛和不适的，手术对周围脊椎的影响 组织是不确定的。手术干预有可能开始人为加速 DDD在表面上健康的椎间盘上的进展。常规T1和T2成像技术 有助于观察椎间盘(IVD)的后期结构形态变化 但对早期的生化变化不敏感。T1？松弛时间已被证明为 对腰椎间盘的早期退变有更高的敏感性和特异性。在这项研究中， 我们使用T1？MRI的能力来检测髓核内的早期生化变化 与接受过脊柱手术的人一起研究健康的腰椎间盘。我们研究的目的是 确定T1？与通过有创途径获得的椎间隙开放压力之间的关系 挑衅性的视盘记录术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Degenerative disc disease (DDD) is the most common cause of back-related disability among North American adults. DDD translates into nearly 100 billion dollars in health-related expenditures in the United States alone. Among those diagnosed with DDD, thousands of individuals undergo corrective spinal surgery such as total disc replacement and lumbar fusion. Even with the prevalence of these surgeries, overall long-term effectiveness of the surgery in regards of total spinal health is unclear. While surgery may treat the specific location that is deemed to be causing pain and discomfort, the effect of the surgery on the surrounding spinal tissue is uncertain. It is possible that surgical intervention may begin to artificially accelerate the progression of DDD on apparently healthy discs. Conventional T1 and T2 imaging techniques are useful for observing late structural morphological changes to the inter-vertebral discs (IVDs) but are insensitive to early biochemical changes. The T1¿ relaxation time has been shown to have enhanced sensitivity and specificity to early degeneration of the spinal discs. In this study, we used the ability of T1¿ MRI to detect early biochemical changes within the nucleus pulposus of healthy discs with individuals who have undergone spinal surgery. The purpose of our study is to determine the relationship between T1¿ and disc opening pressure acquired via invasive provocative discography.