TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 (TRPV1) ANKYRIN REPEAT DOMAIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们感兴趣的是看到C157 S突变的影响，瞬时受体电位香草素1（TRPV 1）锚蛋白重复结构域对ATP结合。这对我们对TRPV 1的许多其他研究工作都有影响-这些研究依赖于设计TRPV 1的功能性半胱氨酸版本-以及TRPV 1通过化学修饰C157对一些辛辣化合物（如大蒜）做出反应的过程的生物学意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in seeing the effect of the C157S mutation within the Transient receptor potential vanilloid 1 (TRPV1) ankyrin repeat domain on ATP binding. This has implications for many of our other research efforts on TRPV1 - which rely on engineering a functional cysteine-less version of TRPV1 - as well as biological implications on the process by which TRPV1 responds to some pungent compounds like garlic through chemical modification of C157.