BISPHENOL A METABOLISM AND EFFECTS IN A PRIMATE MODEL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 双酚A（BPA）是生产中含量最高的化学品之一，美国90%以上的人每天都接触到低水平的双酚A。最近对小鼠的研究表明，暴露于低水平的这种雌激素化学品会对广泛的生物系统产生不利影响。 然而，缺乏关于小鼠研究与人类接触的相关性的信息，这阻碍了利用这些研究为人类健康政策决策提供信息。 来自灵长类动物模型的数据将有助于弥合小鼠和人类之间的差距。 该提案支持对NIH已经资助的赠款的补充活动。 受资助的赠款“胎儿双酚A暴露对灵长类动物卵子发生的影响”涉及用双酚A治疗成年怀孕雌性恒河猴，并评估对雌性胎儿卵子发生的影响。 该项目包括两项额外的活动：1）研究BPA口服后的命运，以确定组织分布和排泄途径，2）资助从NIH资助的正在进行的研究中收集和分发灵长类动物组织给其他护照基金会资助的研究人员。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bisphenol A (BPA) is one of the highest volume chemicals in production, and over 90% of people in the US are exposed to low levels on a daily basis. Recent studies in the mouse indicate that exposure to low levels of this estrogenic chemical adversely affects a wide range of biological systems. However, there is a lack of information about the relevance of mouse studies to human exposure, which has prevented the use of these studies to inform human health policy decisions. Data from a primate model will help to bridge the gap between mouse and human. This proposal supports supplemental activities to an already funded grant from NIH. The funded grant "Effects of Fetal Bisphenol A Exposure on Oogenesis in Primates" involves the treatment of adult, pregnant female rhesus monkeys with BPA and the assessment of effects on oogenesis in female fetuses. This project covers two additional activities: 1) a study of the fate of BPA once it is orally ingested to determine the tissue distribution and excretion pathways and, 2) funds to support the collection and distribution of primate tissues from an ongoing NIH funded study to other Passport Foundation-funded investigators.